Chem Sci Trans., 2013, 2(3), 950-954 Chemical Science Transactions DOI:10.7598/cst2013.494 ISSN/E-ISSN: 2278-3458/2278-3318 Synthesis and Antimicrobial Activities of N′ ′ ′ -[(2-Chloro-6-methoxy quinolin-3-yl)methylidene]- substituted Benzohydrazide SAMIR S. SHAIKH Department of Chemistry, Gramonnati Mandal’s Arts, Comm. & Sci. College, Affiliated to University of Pune, Narayangaon-410504, Pune, Maharashtra, India ss.samir@rediffmail.com Received 18 December 2012 / Revised 26 January 2013 / Accepted 17 February 2013 Abstract: A number of N′-[(2-chloro-6-methoxyquinolin-3-yl) methylidene]-substituted benzohydrazide have been synthesized by the treatment of 2-chloro-6-methoxy-3-quinolinecarbaldehyde with the substituted benzohydrazides. The structures of the synthesized compounds have been characterized by using IR and 1 H NMR spectroscopy. These compounds were screened for their antibacterial as well as antifungal activity. Compounds show grater antibacterial activity as compare to antifungal activity. Keywords: 2-Chloro-6-methoxy-3-quinolinecarbaldehyde, Benzohydrazides, Antimicrobial activities Introduction Hydrazide analogues having azomethine (–CONHN=CH-) group show antimicrobial activities and it also possess other biological activities like anticonvulsant, antidepressant, analgesic 1,2 , anti-inflammatory 3 , antimalarial, anticancer activities. It is also active against experimental tuberculosis in guinea pigs 4,5 . In in-vitro metabolism studies, it has been found that hydrazide-hydrazones undergo hydrolytic reactions and aromatic rings undergo aromatic hydroxylation reactions and give positive effect for cure of diseases 6,7 . Gökhan- Kelekçi et al. synthesized hydrazones containing 5-methyl-2-benzoxazoline 8 . The analgesic effects of 2-[2-(5-methyl-2-benzoxazoline-3-yl) acetyl]-4-chloro- /4-methyl benzylidene hydrazine were found to be higher than those of morphine and aspirin 8 . Hydrazide-hydrazones compounds are not only intermediates but they are also very effective organic compounds in their own right. When they are used as intermediates, coupling products can be synthesized by using the active hydrogen component of – CONHN=CH- azomethine group 9 . In continuation of this work to develop potential antimicrobial molecules 10 , we report here the synthesis of some derivatives by combining two biological active compounds (3-formyl 2-chloro quinolines and substituted benzohydrazides) having azomethine group and characterized by spectral data with evaluation for their antimicrobial activity. RESEARCH ARTICLE