Pathology – Research and Practice 203 (2007) 555–560 TEACHING CASES A solitary fibrous tumor in the broad ligament of the uterus Pavol Zubor a,Ã , Karol Kajo b , Norbert Szunyogh a , Silvester Galo a , Jan Danko a a Department of Obstetrics and Gynecology, Jessenius Faculty of Medicine, Comenius University, Kollarova 2, 03659 Martin, Slovak Republic b Department of Pathological Anatomy, Jessenius Faculty of Medicine, Comenius University, Kollarova 2, 03659 Martin, Slovak Republic Received 12 December 2006; received in revised form 12 February 2007; accepted 19 February 2007 Abstract Solitary fibrous tumor (SFT) is a rare mesenchymal tumor that occurs preferentially in the pleura. Although it has been described at some extrathoracic sites, its occurrence in the female genital tract is extremely rare. We are the first to report on an unusual case of a large (14 cm in the largest diameter) SFT localized in the broad ligament of the uterus in a 50-year-old woman. The patient underwent surgical tumor extirpation and has remained well without any sign of local tumor recurrence after 6 years of follow-up. We discuss the clinical aspects, the gross macroscopic appearance, the histologic findings, and the differential diagnosis, and provide a review of the literature. r 2007 Elsevier GmbH. All rights reserved. Keywords: Solitary fibrous tumor; Extrapleural site; Broad ligament Introduction Solitary fibrous tumor (SFT) is a rare neoplasm that was first described as a tumor in the pleura [28]. Subsequently, over the past decade, its occurrence was also reported at many extrapleural sites, e.g. adrenal glands [36], thyroid gland [40], sublingual glands [33], prostate [25], liver [5], kidneys [13,21], pancreas [6], orbit [38,47], spinal cord [35], breast [4,12], periosteum [32], nasal cavity and the nasopharynx [29], or the medias- tinum [31]. This led to the exclusion of its mesothelial origin, and owing to its positive immunohistochemical staining for CD34, a mesenchymal histogenesis was presumed. The appearance of SFT in humans is sporadic. Only once has a familiar occurrence in the pleura been recorded [27]. SFT usually affects adults between 20 and 70 years of age with no sex predilection. Despite the ubiquitous occurrence of SFT, its presence in the female genital tract is extremely rare, and only nine cases of SFT have been published in the literature to date [1,3,17,22,42–46]. Previously reported cases, including our case, are summarized in Table 1. The clinical behavior of SFT is usually benign, but in some cases, the existence of aggressive forms has been documented both in the pleura and at extrapleural sites [34,45]. We present a case of a primary SFT localized in the broad ligament of the uterus and report on the clinical aspects, the gross macroscopic appearance, the histolo- gic findings, and the differential diagnosis, and give a review of the literature. To our knowledge, the English literature has not yet provided a description of this tumor in the broad ligament. ARTICLE IN PRESS www.elsevier.de/prp 0344-0338/$ - see front matter r 2007 Elsevier GmbH. All rights reserved. doi:10.1016/j.prp.2007.02.005 Ã Corresponding author. Tel.: +421 434 203 242; fax: +421 434 134 185. E-mail address: zubor@jfmed.uniba.sk (P. Zubor).