*Corresponding Author Address: Dr. Prabhakar Kumar Verma, Faculty of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak-124001, India; E-mail:vermapk422@rediffmail.com World Journal of Pharmaceutical Sciences ISSN (Print): 2321-3310; ISSN (Online): 2321-3086 Published by Atom and Cell Publishers © All Rights Reserved Available online at: http://www.wjpsonline.org/ Review Article Triazoles and its pharmacological activities: A Review Prabhakar Kumar Verma* and Mamta Kadawla Faculty of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak-124001, India. Received: 07-09-2016 / Revised: 21-10-2016 / Accepted: 23-11-2016 / Published: 26-11-2016 ABSTRACT Triazole and its derivatives play wide role in drug discovery processes and have considerable chemical significance and biological activities. The triazole derivatives are more than just passive linkers; they readily associate with biological targets, through hydrogen bonding and dipole interactions. In the last years the synthesis of high nitrogen containing heterocyclic nucleus has been attracted to many pharmaceutical industries. Triazole derivatives has a wide range of applications i.e. such as anti-microbial, anti-tumor, anthelmintic, anti- leishmanial, anti-convulsant ,anti-inflammatory, anti-viral, anti-leprotic, anti-depressant, anti-anxiety, antihistamines, antitubercular and analgesic etc. The derivatization of triazole moieties is based on phenomenon of bioisoterism which include replacement of oxygen of oxadiazole nucleus with nitrogen triazole analogue. Keywords: Triazoles Derivatives, anti-microbial, anti-tumour, anthelmintic, anti-leishmanial, anti-convulsant, anti-inflammatory, and analgesic etc. INTRODUCTION In the last very few decades, the chemistry of 1, 2, 4-triazoles as well as their fused heterocyclic derivatives have been receiving considerable attention due to their various synthetic and efficient biological importance. Triazole nucleus have been attracting considerable attention in various field such as medicinal and agrochemical research as well as in material sciences owing to their unique structure and characteristics. The triazoles are said to be the isosters of imidazoles in which the carbon atom of imidazole is isosterically replaced by nitrogen. Triazoles moieties have been incorporated into a wide range of therapeutically interesting drug molecules including anti inflammatory, sedatives, cns stimulants, antianxiety anti fungal activity and antimicrobial agents. They have been used as optical brightening agents, as antioxidants, as corrosion inhibitors and as additives with a variety of other functions. Many dye stuffs and pigments have heterocyclic compounds. The importance of triazole derivatives lies in the field that these have good position in heterocyclic chemistry, due to its different biological activities Therefore, 1,2,4- triazole derivatives have quite attractive properties and have acquired due attention during the last ew decades. Biological activities of Triazole derivatives Triazole derivatives as anti-cancer agents: Cancer is a dreadful disease with a complex pathogenesis, which is threatful for human life greatly. A number of chemotherapeutic drugs have been developed and are being developing to treat cancer including DNA-alkylating agents and antimitotic agents. The current position highlights the need for the discovery and development of new compounds of simple and basic structure, exhibiting optimal in vivo antitumor potency, bioavailability and new mechanisms of action. The research for new drugs that can specifically target the tumour cells is today’s demand of cancer therapy and is a never ending process, till the goal is achieved. The successful non-surgical elimination of cancer cells involves apoptosis. The induction of apoptosis by cytotoxic drugs is not only limited to the malignant cells, normal cells are equally vulnerable. So it is necessary to go for new agents that selectively target tumour cells without perturbing normal tissue. The synthesis of some new compounds and selected to evaluate their in vitro growth inhibitory activities against two human cultured cell lines, which are breast carcinoma cell line (MCF7) and