S1 SUPPLEMENTARY MATERIAL Three-Dimensional Quantitative Structure-Selectivity Relationships Analysis Guided Rational Design of a Highly Selective Ligand for the Cannabinoid Receptor 2 Simone Brogi, Federico Corelli, Vincenzo Di Marzo, Alessia Ligresti, Claudia Mugnaini, Serena Pasquini and Andrea Tafi* Contents : R-Table of CB2 ligands used to develop 3D-QSSR models page S2-S5 R-Table of CB2 ligands included in the external test set page S6-S7 CB2 Pharmacophore Modeling page S8-S16 References page S16-S17