Nutrition and chronic diseases II 153 BMI below 18.5 kg/m 2 was confirmed in 25% (20/80) of patients, protein malnutrition (low albumin) in 50% (40/80) of patients, reduced values of vitamins B9 and B12 in 36% (29/80) of patients. Conclusion: In patients with advanced liver cirrhosis, different pathological mechanism, such as inadequate of- fer and impaired absorption of nutrients, hypermetabolic state and diminished synthetic capacity of the liver are the main reasons that lead to malnutrition. Identifying patients that are approaching the state of malnutrition is necessary in order to provide nutritional support to those that need it most. Disclosure of Interest: None Declared PP101-MON PATIENTS WITH SHORT BOWEL SYNDROME TREATED WITH BOVINE COLOSTRUM TO IMPROVE INTESTINAL FUNCTION; A DOUBLE BLINDED, PLACEBO CONTROLLED, CROSS-OVER, PILOT STUDY P. Lund 1 , P.T. Sangild 2 , L. Aunsholt 3 , B. Hartmann 4 , J.J. Holst 4 , J. Mortensen 5 , P.B. Mortensen 1 , P.B. Jeppesen 1 . 1 Dept. of Gastroenterology, Rigshospitalet, 2 Dept. of Human Nutrition, Copenhagen University, Cph, 3 Dept. of Paediatrics, Odense University Hospital, Odense, 4 Dept. of Endocrinology Research, Copenhagen University, 5 Dept. of Clinical Physiology and Nuclear Medicine, Rigshospitalet, Cph, Denmark Rationale: Additional therapeutic options for treatment of short bowel syndrome (SBS) are desired. Colostrum, raw milk, is rich in immunoregulatory, antimicrobial and trophic components that stimulates intestinal develop- ment and function in newborns. This study investigated, if bovine colostrum enhanced intestinal adaptation and function in adult SBS patients. Methods: 12 SBS patients, 5 female, 7 male, 56±11 years, with a remnant small bowel length of 177±97 cm, 5 with colon, received in random sequence; 4 weeks intake of 500 ml/d colostrum or an iso-protein-energy placebo (~2.5 MJ/d, 34% protein) added to their regular diet, separated by a 4-week wash-out period. At 4 hospital ad- missions 72-hours fluid, electrolyte and nutrient balance studies, testing of hand grip strength, lung function tests and measures of body composition were done. Results: Per protocol results were obtained in 8 patients. Both protein-energy supplements (colostrum, placebo) in- creased absolute protein (~0.9 MJ/d, p  0.0004) and en- ergy (~1.5 MJ/d, p  0.011) absorption compared to base- line measurements (Student’s t-test). However, faecal wet weight excretion was increased (~250 g/d, p  0.034) during both treatments. Increased protein/energy intake and uptake led to improvement of handgrip strength (p  0.035) and for placebo an almost 1 kg increase in lean body mass (p = 0.049). Colostrum did not benefit overall intestinal protein or energy absorption compared to placebo. Conclusion: Benefit of oral protein-energy supplement was established, but it was at the expense of increased fecal wet weight excretion. Colostrum was not superior to placebo. Disclosure of Interest: None Declared PP102-MON NUTRITIONAL SUPPORT IN CHRONIC OBSTRUCTIVE PULMONARY DISEASE (COPD): A SYSTEMATIC REVIEW AND META-ANALYSIS P.F.Collins 1 , R.J. Stratton 1 , M. Elia 1 . 1 Institute of Human Nutrition, University of Southampton, Southampton, United Kingdom Rationale: A Cochrane review concluded nutritional support in COPD had no effect on anthropometry and functional outcomes [1] but other reviews suggest this may not be so [2]. This review aimed to clarify the current evidence base. Methods: A systematic review identified 13 randomised controlled trials (n 419) of nutritional support (dietary advice, oral nutritional supplements (ONS), tube feeding) vs. control. Meta-analysis was performed of nutritional in- take, weight, mid-arm muscle circumference (MAMC) and handgrip strength (HGS) (Comprehensive Meta-analysis v2). In contrast to previous Cochrane reviews, which examined only data at the end of intervention, this review examined the changes induced by the intervention. Results: Eleven of the 13 studies used ONS. Meta-analysis found nutritional support significantly increased energy intake (227 SE 53 kcal/d, p < 0.001, fixed effect model), body weight (1.95 SE 0.24 kg, p < 0.001 (undernourished) and 1.3 SE 0.34 kg, p < 0.001 (nourished)) and HGS (5.3 SE 2.7%, p < 0.05 random effects model). Where data on dispersion was not available, significant improvements were also found using mean values (one-sample t-test) for MAMC (3%, range 0.7 7%, p = 0.034) and protein intakes (17 SD 6.7 g/d, p = 0.005). Conclusion: In contrast to the findings of a Cochrane review, this review concludes that nutritional support, mostly involving ONS, significantly improves nutritional intake, body weight, muscle mass and HGS in COPD. References [1] Ferreira I et al., (2005) Cochrane Database of Systematic Reviews 2005 Issue 2. [2] Stratton RJ et al., (2003) Disease-related malnutrition: an evidence-based approach to treatment, CABI: Oxford. Disclosure of Interest: P. Collins: None Declared, R. Stratton Other: Nutricia Ltd., M. Elia: None Declared PP103-MON NUTRITIONAL SUPPORT AND FUNCTIONAL CAPACITY IN CHRONIC OBSTRUCTIVE PULMONARY DISEASE (COPD): A SYSTEMATIC REVIEW AND META-ANALYSIS P.F.Collins 1 , R.J. Stratton 1 , M. Elia 1 . 1 Institute of Human Nutrition, University of Southampton, Southampton, United Kingdom Rationale: Controversies exist about the value of using nutritional support to improve functional outcomes in COPD with a Cochrane review reporting no evidence of benefit [1]. This updated review aimed to re-examine the evidence base. Methods: A systematic review identified 13 randomised controlled trials (n 419) of nutritional support (dietary advice (n 1), oral nutritional supplements (n 11) or enteral tube feeding (n 1)) versus control in COPD. Respiratory muscle strength (PI max and PE max),