J Cutan Pathol 2012: 39: 444 – 448 doi: 10.1111/j.1600-0560.2012.01863.x John Wiley & Sons. Printed in Singapore Copyright  2012 John Wiley & Sons A/S Journal of Cutaneous Pathology Eruptive tumors of the follicular infundibulum presenting as hypopigmented macules on the buttocks of two Black African males We report two cases of eruptive tumors of the follicular infundibulum (TFI) with an unusual clinical presentation which has not been described previously in literature. In both cases, the appearance was strikingly similar, consisting of multiple asymptomatic hypopigmented macules on the buttocks of two Black African males, aged 38 and 55 years old. In both cases, the eruption had evolved over several months. The individual lesions were of similar size, approximately 1 cm, with irregular and ill-defined borders. Histopathological examination revealed a superficial and horizontal plate-like proliferation of keratinocytes emanating from the epidermis with multiple slender attachments. Pale keratinocytes were present within the epithelial plates. A Fontana stain showed a loss of melanin pigment from the epithelial plates. Orcein (elastic) stain highlighted an increase of the number of the elastic fibers surrounding the tumor. On the basis of these findings, a diagnosis of eruptive TFI was established for both cases. Among the various presentations of TFI, only the eruptive variant appears to be clinically distinctive, with asymptomatic hypopigmented macules usually located on the face, neck and upper trunk. Eruptive TFI should also be added to the clinical differential diagnosis of multiple hypopigmented macules on the buttocks of Black patients. Keywords: buttocks, eruptive, hypopigmentation, tumor of the follicular infundibulum Kolivras A, Moulonguet I, Ruben BS, Sass U, Cappelletti L, Andr´ e J. Eruptive tumors of the follicular infundibulum presenting as hypopigmented macules on the buttocks of two Black African males. J Cutan Pathol 2012; 39: 444 – 448.  2012 John Wiley & Sons A/S. Athanassios Kolivras 1 , Isabelle Moulonguet 2 , Beth S. Ruben 3,4 , Ursula Sass 1 , Letizia Cappelletti 5 and Josette Andr ´ e 1 1 Department of Dermatology and Dermatopathology, Saint-Pierre Hospital, Universit´ e Libre de Bruxelles, Brussels, Belgium, 2 Private Dermatopathology practice, Paris, France, 3 Department of Dermatology, University of California, San Francisco, CA, USA, 4 Department of Pathology, University of California, San Francisco, CA, USA, and 5 Department of Dermatology, Saint-Pierre Hospital, Universit´ e Libre de Bruxelles, Brussels, Belgium Athanassios Kolivras, Department of Dermatology and Dermatopathology,Saint-Pierre Hospital, Universit´ e Libre de Bruxelles, Brussels, Belgium Tel: +32 2 5354379 Fax: +32 2 5354381 e-mail: kolivras@gmail.com Accepted for publication December 26, 2011 Tumor of the follicular infundibulum (TFI) was ini- tially described by Mehregan and Butler in 1961. 1 Since then, several reports based on the various clin- ical and histopathological aspects of TFI have been published in literature. TFI usually presents in soli- tary fashion on the face, scalp, neck or upper trunk. Other presentations include an eruptive variant, TFI associated with Cowden’s disease, TFI associated with other tumors or hamartomas, such as nevus sebaceous, and TFI-like reactive epidermal change. 2 Among the various presentations of TFI, only the eruptive variant appears to be clinically distinctive and it has been reported to consist of asymptomatic, hypopigmented, irregularly shaped macules involv- ing the face, neck and upper trunk. 2–4 We present two cases of eruptive TFI with a novel clinical pre- sentation. In both cases, the cutaneous eruption consisted of multiple asymptomatic hypopigmented macules on the buttocks of Black African males. The diagnosis was not suspected clinically, and the correct 444