Hepatoprotective Activity of Of Naringin Against Acute Hepatotoxicity in Rats Hussein M. Badr  , Abdallah M. Ashour  and Attalla F. El-kott   Animal Production Dept., Faculty of Agriculture, Al-Azhar University, Egypt  Zoology Dept., Faculty of Science, Fayoum University, Egypt  Zoology Dept., Faculty of Science, 7April University, Libya The 3 rd Conference of Basic Science; 25 –  in Faculty of Science Elgabel Algharby University, Libya Abstract The hepatoprotective effects of naringin pre-treatment against carbon tetrachloride (CCL  )-induced liver damage in rats were investigated. Carbon tetrachloride (0.5 mL kg - body weight) was administered. The degree of protection naringin was measured by using biochemical parameters such as serum ALT, AST, ALP and bilirubin, also by hematological and histological investigations in four animal groups (control, Naringin, CCL  and CCL  with Naringin treated groups). The results revealed the hepatoprotective effects of naringin in group CCL  treated with naringin, where the significant decrease (P in ALT, AST and bilirubin in normal values as similar as in control group. Also in the same group, the haematological results revealed the significant (P increase the haemoglobin, RBCs to normal counts as similar as in control. Also, histological examination of the liver revealed severe infiltration of inflammatory cells in rats treated with CCL  alone. However, the observed alteration in the normal architecture of the hepatic cells decreased remarkably in pre-treated rats with naringin. In conclusion, the results reported here indicate that naringin exerts a preventive effect on CCl  -induced haematology and liver damage in rats, possibly through its antioxidant action. We therefore propose that naringin supplementation therapy in patients exposed to toxic doses of CCL  may be beneficial in reducing tissues damage. Keywords: Carbon tetrachloride, Naringin, hepatotoxicity, Liver functions, haematology