identified it as belonging to the family of dematiaceous
fungi.
The patient was not immunocompromised. No antifun-
gal therapy was administered. The patient did well after
excision of the lesion, and there was no recurrence of
disease.
Fungal isolates from the conjunctival sac are not un-
common; they occur in 5% to 10% of normal eyes.
1
Nevertheless, fungal infection is rarer in the conjunctiva
than in other ocular structures. In the immunocompetent
host, pathogenic fungi, such as Coccidioides immitis and
Sporothrix schenckii
2
in Western countries and Rhinosporid-
ium seeberi in tropical environments,
3
cause the majority of
conjunctival mycosis. In the immunocompromised host or
in patients whose conjunctival defenses have been weak-
ened by prolonged corticosteroid or antibiotic use, fungal
infection occurs more commonly, although it is still rare.
4
Among the fungal infections of the conjunctiva in these
two groups, fungi that mimic neoplasms are rare. To our
knowledge, there has been one report of a fungal infection
of the eyelid that presented as a tumor.
5
The fungus isolated from the patient described was a
member of the Dematiaceae family in the order Moniliales.
These organisms produce simple conidiophores and have
dark brown or black hyphae or spores. This characteristic
produced the melanotic hue of this lesion and a close
resemblance to conjunctival melanoma, which prompted
the excision.
Because the overall mortality rate for melanoma of the
conjunctiva has been reported to be as high as 26%,
5
it is
imperative that the physician be prompt in diagnosing and
treating such lesions. When considering a differential
diagnosis, the possibility of fungi, although rare, should be
entertained.
REFERENCES
1. Ando N, Takatori K. Fungal flora of the conjunctival sac.
Am J Ophthalmol 1982;94:67–74.
2. Wilson LA, Ajello L. Agents of oculomycosis: fungal infec-
tions of the eye. In: Collier L, Balows A, Sussman M, editors.
Topley and Wilson’s microbiology and microbial infections,
9th ed. Vol. 4. London: Arnold, 1998:525–567.
3. Shrestha SP, Hennig A, Parija SC. Prevalence of rhinospo-
ridiosis of the eye and adnexa in Nepal. Am J Trop Med Hyg
1998;59:231–234.
4. Waddell KM, Sebastian LB, Downing RG. Case reports and
small case series: conjunctival cryptococcosis in the acquired
immunodeficiency syndrome. Arch Ophthalmol 2000;118:
1452–1453.
5. Folberg R, McLean IW, Zimmerman LE. Malignant mela-
noma of the conjunctiva. Hum Pathol 1985;16:136 –143.
Intraocular Caterpillar Setae Without
Subsequent Vitritis or Iridocyclitis
Michael S. Ibarra, MD, Stephen E. Orlin, MD,
Bruce R. Saran, MD, Robert P. Liss, MD, and
Albert M. Maguire, MD
PURPOSE: To report a case of caterpillar setae embedded
in the corneal stroma and inferotemporal retina with
minimal inflammation.
DESIGN: Observational case report.
METHODS: A 4-year-old boy developed a red eye after
playing with a caterpillar. He was placed on topical
tobramycin/dexamethasone and referred for evaluation of
embedded setae in his conjunctiva, cornea, iris, and
retina. Examination revealed no iridocyclitis or vitritis.
RESULTS: Because of the lack of intraocular inflammatory
response, no invasive intervention was conducted to
remove or destroy the setae and he was tapered off the
tobramycin/dexamethasone. At 4-month follow-up he
remained asymptomatic with the setae still present in
both his cornea and retina. In addition, vitreous mem-
branes had formed in the immediate vicinity of the
intraretinal setae.
CONCLUSION: Intraretinal and corneal setae can be em-
bedded with minimal inflammation and can be tolerated
without need for surgical intervention. (Am J Ophthal-
mol 2002;134:118 –120. © 2002 by Elsevier Science
Inc. All rights reserved.)
A
4-YEAR-OLD BOY WAS REFERRED FOR EVALUATION OF
asymptomatic corneal, iris, and retinal foreign bodies
in his right eye. Three weeks prior, the boy had been
playing with a caterpillar and subsequently developed a red
Accepted for publication March 6, 2002.
From the Department of Ophthalmology, Scheie Eye Institute, Uni-
versity of Pennsylvania, Philadelphia, Pennsylvania.
Inquiries to Michael S. Ibarra, MD, Department of Ophthalmology,
Scheie Eye Institute, University of Pennsylvania, 51 N 39th St, Phila-
delphia, PA 19104.
FIGURE 2. Periodic acid–Schiff stain of the lesion shows
fungal elements (open arrow), surrounding area of chronic
inflammation (closed arrows), and conjunctival epithelium
(star).
AMERICAN JOURNAL OF OPHTHALMOLOGY 118 JULY 2002