ﻣﺎﻫﻨﺎﻣﻪ ﻋﻠﻤﯽ ﭘﮋوﻫﺸﯽ داﻧﺸﮕﺎه ﻋﻠﻮم ﭘﺰﺷﮑﯽ ﮐﺮﻣﺎﻧﺸﺎه- ﺳﺎل ﻫ ﯿ ﺠﺪﻫﻢ، ﺷﻤﺎره دوم، اردﯾﺒﻬﺸﺖ1393 ) 1 ( Comparison of the effect of accelerated and classic vaccination schedules against Hepatitis B on the short-term production of protective antibody level: a meta-analysis study Siavash Vaziri 1 , Behdad Pakseresht 1 , Alireza Janbakhsh 1 , Babak Sayad 1 , Fiezollah Mansouri 1 , Mandana Afsharian 1 , Omid Beiki 2 * 1. Dept. of Infectious and Tropical Diseases, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran. 2. Research Center for Environmental Determinants of Health, Kermanshah University of Medical Sciences, Kermanshah, Iran. Received: 25 November, 2013 Accepted: 22 April, 2014 Abstract Background: Hepatitis B is a common viral disease and one of the most common causes of cirrhosis and Hepatocellular Carcinoma (HCC). This disease is preventable via vaccination in most individuals. The aim of this study was to compare the accelerated and classic vaccination schedules against hepatitis B in the short-term production of protective antibody level. Methods: A couple of scientific internet resources were searched to find the relevant studies. The abstracts of 156 studies and full texts of some of them were reviewed and finally, 19 articles relevant to the objective of the study were selected. From among the 19 articles remained, 11 articles with a score of 3 out of 5 (JADAD SCORE) were included as high quality studies. Results: The antibody level of 10 mIU/ml or above was considered as positive vaccination response. According to the results of random effect model, no statistically significant difference was reported between the accelerated and conventional vaccination methods in terms of serum protection (OR=0653, CI: 0.425-1.004). However, it seems that the accelerated method is less strong. Conclusion: Although it seems accelerated vaccination method has less power, the difference has been trivial in most of the studies. Accelerated vaccination is recommended in situations where faster protective antibody level is needed. Keywords: Hepatitis B, conventional vaccination method, accelerated vaccination method, meta-analysis J Kermanshah Univ Med Sci. 2014; 18(2): 92-99 * Corresponding author: Reseearch Center for Environmental Determinants of Health, Kermanshsh University of Medical Sciences, Kermanshah, Iran. Tel: +989188887382 Email: omid.beiki@yahoo.com References 1. Koziel MJ, Thio CL. Hepatitis B Virus and Hepatitis Delta Virus. In: Mandell GL, Bennett JE, Dolin R. Principles and Practice of Infectious Disease. 7 th ed. Philadelphia: Churchill Livingstone. 2010;2059-86. 2. Michel ML, Tiollais P. Hepatitis B vaccines: protective efficacy and therapeutic potential. Pathol Biol (Paris). 2010;58(4):288-95. 3. Van Herck K, Leuridan E, Van Damme P. Schedules for hepatitis B vaccination of risk groups: balancing immunogenicity and compliance. Sex Transm Infect. 2007;83(6):426-32. 4. Saltoğlu N, Inal AS, Tasova Y, Kandemir O. Comparison of the accelerated and classic vaccination schedules against Hepatitis B: three-week Hepatitis B vaccination schedule provides immediate and protective immunity. Ann Clin Microbiol Antimicrob. 2003;2:10. 5. Bock HL, L?scher T, Scheiermann N, Baumgarten R, Wiese M, Dutz W, et al. Accelerated Schedule for Hepatitis B Immunization. J Travel Med. 1995;2(4):213-7. 6. Ghadiri K, Vaziri S, Afsharian M, Jahanbaksh A, Mansouri F, Sayad M, et al. Comparison of the accelerated and standard vaccination schedules against hepatitis B in healthcare workers. J Res Med Sci. 2012;17(10):934- 7. 7. de Vries-Sluijs TE, Hansen BE, van Doornum GJ, Kauffmann RH, Leyten EM, Mudrikova T, et al. A randomized controlled study of accelerated versus standard hepatitis B vaccination in HIV-positive patients. J Infect Dis. 2011;203(7):984-91.