Open Journal of Obstetrics and Gynecology, 2017, 7, 51-60 http://www.scirp.org/journal/ojog ISSN Online: 2160-8806 ISSN Print: 2160-8792 DOI: 10.4236/ojog.2017.71006 December 30, 2016 Efficacy of Intra-Cystic Methotrexate Injection in Management of Benign Persistent Ovarian Cysts Adel El Gergawy, Ahmed El Halwagy, Ayman S. Dawood * Department of Obstetrics and Gynecology, Faculty of Medicine, Tanta University, Tanta, Egypt Abstract Aim: To evaluate and compare the efficacy of methotrexate injection in management of persistent simple ovarian cyst versus the use of transvaginal ultrasound aspiration alone. Patients and Methods: This randomized controlled study was conducted at Tanta University Hospitals in the period from April 1, 2016 to October 31, 2016. Pa- tients were randomly allocated into two groups; each group has 25 patients with be- nign persistent simple ovarian cyst. Group I: Patients were subjected to transvaginal aspiration of the cyst. Group II: patients were subjected to methotrexate injection inside the cyst. Patients in both group were followed up at 1, 3, 6 months after pro- cedure for the recurrence and occurrence spontaneous pregnancy. Results: The mean age in group I was 28.8 years, and the mean age in group II was 26.52 years with non-significant difference. Also there was non-significant difference between both groups regarding size of the cyst. No case recorded to have a cyst recurrence in group II and four cases in group I within six months with significant difference (P value 0.037), and there was non-significant differences as regard the pregnancy rate and complications. Conclusion: Transvaginal intra-cystic methotrexate injec- tion is a safe and effective choice for management of persistent simple benign ova- rian cyst. Keywords Simple Cyst, Methotrexate, Ultrasound Guided, Aspiration, Recurrence 1. Introduction Ovarian cysts are common findings in women throughout their lifetime. Ovarian cysts include three main types: functional, benign or malignant. Benign cysts are by far the most common in the great majority of cases. Benign cysts usually can be managed con- servatively. Some ovarian cysts are symptomatic and may require surgical management. The incidence of cystic ovarian lesions ranges from 5% to 15% [1]. How to cite this paper: El Gergawy, A., El Halwagy, A. and Dawood, A.S. (2017) Ef- ficacy of Intra-Cystic Methotrexate Injec- tion in Management of Benign Persistent Ovarian Cysts. Open Journal of Obstetrics and Gynecology, 7, 51-60. http://dx.doi.org/10.4236/ojog.2017.71006 Received: November 16, 2016 Accepted: December 27, 2016 Published: December 30, 2016 Copyright © 2017 by authors and Scientific Research Publishing Inc. This work is licensed under the Creative Commons Attribution International License (CC BY 4.0). http://creativecommons.org/licenses/by/4.0/ Open Access