Fitoterapia 75 (2004) 134–140 0367-326X/04/$ - see front matter  2003 Elsevier B.V. All rights reserved. doi:10.1016/j.fitote.2003.11.005 Two new cytotoxic isoprenylated flavones, artoindonesianins U and V, from the heartwood of Artocarpus champeden Yana M. Syah , Sjamsul A. Achmad *, Emilio L. Ghisalberti , a a, b Euis H. Hakim , Didin Mujahidin a a Department of Chemistry, Institut Teknologi Bandung, Jalan Ganesha 10, Bandung 40132, Indonesia a Department of Chemistry, The University of Western Australia, Crawley, WA 6009, Australia b Received 29 October 2002; accepted 26 November 2003 Abstract Two new isoprenylated flavones, artoindonesianins U (1) and V (2), have been isolated from the heartwood of Artocarpus champeden together with three known isoprenylated flavonoids, 59-hydroxycudraflavone A, cyclocommunin and artonin B. The structures of the new flavones were elucidated on the basis of spectroscopic evidence. Both compounds 1 and 2 showed strong cytotoxic activity against P-388 cell lines.  2003 Elsevier B.V. All rights reserved. Keywords: Artocarpus champeden Spreng; Artoindonesianins U and V; Artonin B; Cyclocommunin; Cytotoxicity; 59-Hydroxycudraflavone A; Isoprenylated flavones; Moraceae; P-388 cells 1. Introduction Previously, we reported the isolation of some biologically-active isoprenylated flavones from the Indonesian plant Artocarpus champeden, locally known as ‘cempedak’ w1–3x. In continuation of our search for bioactive compounds from moraceous plants, we have undertaken a more detailed examination of the metabo- lites from this species. In this paper, we report the isolation, structure elucidation and biological evaluation of two new isoprenylated flavones, which we have trivially *Corresponding author. Fax: q62-22-250-4154. E-mail address: sjamsul@indo.net.id (S.A. Achmad).