This is an Accepted Article that has been peer-reviewed and approved for publication in the Experimental Physiology, but has yet to undergo copy-editing and proof correction. Please cite this article as an Accepted Article; doi: 10.1113/EP086068. This article is protected by copyright. All rights reserved. Ghrelin ameliorates blood brain barrier disruption in the systemic hypoxia Gisou Mohaddes 1 , Jalal Abdolalizadeh 2 , Shirin Babri 1 , Fezzeh Hossienzadeh 1, 3 1 Neuroscience Research Center of Tabriz University of Medical Sciences, Tabriz, Iran 2 Drug Applied Research Center, Tabriz University of Medical Sciences-Tabriz-Iran 3 Faculty of Medicine Sciences, Sarab, Tabriz University of Medical Sciences, Tabriz, Iran Correspondence to: Fezzeh Hossienzadeh, Faculty of Medical Sciences, Sarab, Tabriz University of Medical Science, Tabriz, Iran. Tel. /fax: +98-41-43237981. Email: Hossenzadeh_Fez@yahoo.com Running Title: Ghrelin and blood brain barrier in the hypoxia Key word: hypoxia; blood brain barrier; ghrelin Word Count: 4036 The number of references: 36