Paper ID: 386 Association between Admission Blood Glucose Level and In- Hospital Cardiovascular Mortality and Prognosis in Patients with Acute Myocardial Infarction Mrs maryam ardeshiri 1 ،Dr negar salehi 2 ،Dr mogdeh Nasiri Ahmadabadi 2 ،Dr amir reza azizian 3 Abstract: BACKGROUND: Increased level of serum blood on admission is associated with an increased risk of mortality in patients with acute myocardial infarction. However, it is not clear whether this association presents in Iranian patients with acute myocardial infarction. Objective: The aim of this study was to assess an association between elevated blood glucose level on admission and in-hospital cardiovascular mortality and prognosis in Iranian patients with acute myocardial infarction. METHODS: The study population consisted of 396 consecutive patients with acute myocardial infarction from April, 2007 to April, 2009. Admission blood sample of all patients were analyzed for serum glucose level and patients followed for in-hospital mortality and complications. Patients were stratified to four groups based on their serum glucose levels on admission (G1: < 140 mg/dl, G2: 140-199 mg/dl, G3: 200-249 mg/dl, G4: ≥250 mg/dl). Binary logistic regression model was used for estimating adjusted association between glucose level on admission and in-hospital mortality. RESULTS: The mean age of study population was (59.9±12.57) and 299 (75.5%) were men. Mean level of admission glucose level was183.82 mg/dl. In-hospital mortality was 7.1% in G1 group comparing to 22.8% in G4 group (p = 0.001). After adjustment for confounding variables, higher serum glucose level on admission and age were associated with more in- hospital mortality (adjusted OR 1.56, CI 95% 1.18-2.08, p = 0.002; adjusted OR 1.05, CI 95% 1.02-1.09, p = 0.001, respectively). Discussion: There are evidences of increased CADs in Iran. Hyperglycemia is associated with larger infarct size , lower LVEF, and poor prognosis. Moreover, high glucose level is an important role in short- and long-term prognoses of AMI patients. The present study shows that patients with STEMI and hyperglycemia on admission have a higher risk of in-hospital mortality comparing with those without hyperglycemia. This increased risk of mortality is independent of diabetes history. CONCLUSION: 1) shahid rajaie research center : ardeshiri2003@yahoo.com 2) shahid rajaie research 3) shahid rajaie research center