Case Report Disseminated Histoplasmosis with Oral Manifestation in an Immunocompetent Patient Debopriya Chatterjee, 1 Aishwarya Chatterjee, 2 Manoj Agarwal, 3 Meetu Mathur, 4 Setu Mathur, 1 R. Mallikarjun, 5 and Subrata Banerjee 6 1 Department of Periodontics, Government Dental College, Jaipur, India 2 SMS Dental Department, SMS Medical College, Jaipur, India 3 Department of Endodontics, Government Dental College, Jaipur, India 4 Department of Endodontics, Rajasthan Dental College, Jaipur, India 5 Department of Prosthodontics, AB Shetty Dental College, Karnataka, India 6 Department of Medicine, SMS Medical College, Jaipur, India Correspondence should be addressed to Debopriya Chatterjee; banerjee.debo@gmail.com Received 3 June 2016; Accepted 14 August 2016; Published 31 January 2017 Academic Editor: Adriano Loyola Copyright © 2017 Debopriya Chatterjee et al. his is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. A case of disseminated histoplasmosis (DH) in a 60-year-old female patient is reported from Jaipur, Rajasthan, India. he patient presented with multiple papules on the skin surrounding the lips, face, torso, trunk, and back. She also complained of growth in the palate. Histoplasmosis was conirmed by biopsy and histopathology of skin and palatal lesions. his case report highlights the presenting features and occurrence of histoplasmosis in nonendemic region in India. 1. Introduction Histoplasmosis is a dimorphic fungus, which grows in the yeast form in infected tissues. It was irst identiied by Samuel Darling in 1905, hence known as Darling’s disease. Infection is mainly caused by inhalation of droppings from infected birds or bats. Histoplasma capsulatum mainly infects the lungs and passes asymptomatically to involve the skin and reticuloendothelial system [1]. Clinically, histoplasmosis has been classiied as (i) pri- mary acute pulmonary, (ii) chronic pulmonary, (iii) dissemi- nated form, and (DH) occurring in infants, elderly, or immun- ocompromised patients [2]. In human immunodeiciency virus (HIV) positive patients, 95% of histoplasmosis appears as disseminated infection. Occurrence of disseminated form of histoplasmosis is very rare in HIV seronegative patients [3]. he manifestations of disseminated form of histoplasmo- sis are fever, weakness, weight loss, hepatosplenomegaly, and mucocutaneous lesions. he oral lesions may occur in any part of the oral cavity and the lesions vary from nodules to painful shallow or deep ulcers [4]. he incidence of oral manifestation is 25–45% in the disseminated form of the disease [3]. Skin lesions range from papules and plaques with or without crusts, pustules and nodules to mucosal ulcers and erosions, molluscum contagiosum-like lesions, acneiform eruptions, erythematous papules, and keratotic plaques [5]. Although worldwide in distribution, in India, histoplas- mosis seems to be prevalent in the Gangetic delta. Panja and Sen reported the irst case of disseminated histoplasmosis from Calcutta in 1954 and since then individual cases have been reported from various states, mostly from West Bengal. Among the forms of histoplasmosis reported from India, disseminated histoplasmosis is the rarest [1]. 2. Case Report A 60-year-old female was referred from a private practitioner to Dental Department of SMS Medical College Jaipur, with swelling of lower limbs and abdomen for past 3 months. She Hindawi Publishing Corporation Case Reports in Dentistry Volume 2017, Article ID 1323514, 4 pages https://doi.org/10.1155/2017/1323514