ISSN: 2320-5407 Int. J. Adv. Res. 5(1), 83-88 83 Journal Homepage: - www.journalijar.com Article DOI: 10.21474/IJAR01/2723 DOI URL: http://dx.doi.org/10.21474/IJAR01/2723 RESEARCH ARTICLE HISTO-MORPHOMETRICAL STUDY ON KIDNEY GLOMERULI AND CORTICAL TUBULE IN LATE PREGNANCY. Asawer K.M. Al- fatlawee 1 , May F.M. Al-Habib 2 and Mohammad Oda Selman 1 . 1. High institution for infertility diagnosis and ART, Al Nahrin University. 2. Collage of Medicine, Al Nahrin University. …………………………………………………………………………………………………….... Manuscript Info Abstract ……………………. ……………………………………………………………… Manuscript History Received: 15 November 2016 Final Accepted: 17 December 2016 Published: January 2017 Key words:- Pregnancy, histo-morphometry, kidney. Background: Maternal accommodation to normal pregnancy begins shortly after conception,during pregnancy the anatomical and histological changes occur in the kidneyas a maternal adaptation for physiological changes. Aim: Evaluation morphological changes in the kidney glomeruli and tubules during pregnancy, Histomorphometrical assessment of glomeruli and tubular changes with pregnancy. Material and Method: This study carried on 40 mature mice divided into two groups, 20 pregnant mice served as experimental group and 20 non-pregnant mice as a control group, kidneys were removed; the weight is measured and then fixed, dehydrated in ascending grades of alcohol, cleared in xylene and infiltrated with paraffin. The paraffin blocks were made and 5μm thin sections were obtained using a rotary microtome. The sections were stained with H&E stain, PAS examined under light microscope. Result: Under the light microscope, the kidney in experimental group show the many anatomical changes as increase in Wight, elongated and increase in width, and showed many histological changes as a glomerular enlargement with decrease of urinary space and dilation in proximal and distal tubule. A statistically significant differences have been shown in the diameter of renal corpuscle, glomerular tuft and Bowman’s space, and also in the renal tubules proximal and distal convoluted tubules (p<0.001). And in Wight, elongation and width as (p<0.001). Conclusion: The results of the present study indicated during pregnancy kidney undergo to anatomic change as increase in size and Wight, and histologic change as elongation in glomeruli, and dilation in diameter of tubule. Copy Right, IJAR, 2016,. All rights reserved. …………………………………………………………………………………………………….... Introduction:- Pregnancy causes definite and marked changes in urinary tract. The most important changes as dilation of the ureter and kidney pelvis, this phenomena is common and might well be said normal concomitant of pregnant state (1). All mammalian kidney show a morphohistological feature which describe as a cortex enclosing a pyramid-shaped medulla, the tip of which protrudes into the renal pelvis, the medulla is divided into an outer and an inner medulla; Corresponding Author:- Asawer K.M. Al- fatlawee. Address:- High institution for infertility diagnosis and ART, Al Nahrin University.