Available online at www.derpharmachemica.com Scholars Research Library Der Pharma Chemica, 2013, 5(5):77-81 (http://derpharmachemica.com/archive.html) ISSN 0975-413X CODEN (USA): PCHHAX 77 www.scholarsresearchlibrary.com Multi component, one-pot synthesis of (1-(4-(1H-imidazol-1-yl) phenyl)-1, 2- dihydronaptho[1, 2-e] [1, 3]-3-thione and 3-one derivatives under microwave- assisted conditions Ravi Kumar Ganta* a , Venkateswara Rao B. a , Muralikrishna Krishna Kumar M. b , Paul Douglas S. a , Sivaprasadu G. c and Brahmayya M. a a Department of Engineering Chemistry, Andhra University, Visakhapatnam, India b Department of Pharmacy, Andhra University, Visakhapatnam, India c Eisai Pharma Technology and Manufacturing Pvt. Ltd, Visakhapatnam, India _____________________________________________________________________________________________ ABSTRACT 1-(4-(1H-imidazol-1-yl) phenyl)-1, 2-dihydronaptho [1, 2-e] [1, 3]-3-thione and 3-one Derivatives Were moderate high yields using a novel, facile, and one synthesized in pot condensation of β- Napthol, 4-(1H-imidazol-1-yl) benzaldehyde and urea (or) thio urea derivatives under Microwave conditions Key words: 4-(1H-imidazol-1-yl) benzaldehyde, β- napthol, multi-component, Micro wave assisted Conditions _____________________________________________________________________________________________ INTRODUCTION The construction of new analogs of bioactive heterocyclic compounds represents a Major challenge in synthetic organic and medicinal chemistry [1]. Imidazoles are an important class of heterocyclic’s and include many substances of both biological and chemical interest. They are part of a large number of highly significant biomolecules such as the essential amino acid histidine and related compounds, biotin, and the imidazole alkaloids. Insertion of the imidazole nucleus is an important synthetic strategy in drug discovery. Imidazole drugs have broad applications in many areas of clinical medicine. Due to their broad spectrum of biological activities naphthalene- condensed 1, 3-oxazin-3-ones have been reported to act as antibacterial agents, such as HIV-1 reverse transcriptase inhibitors [2]. They have been used as precursors in the preparation of phosphinic ligands for asymmetric catalysis [3]. Recently, a few methods for the synthesis of 1, 2-dihydro-1-arylnaphtho [1, 2-e] [1, 3] oxazine-3-ones have been reported. Generally they are synthesized by three component condensation of urea or thiourea with an aldehyde and β- naphthol, which entails the use of pTSA [4], perchloric acid supported on silica [5], montmorillonite K10 [6], phosphomolybdic acid [7], Iodine [8], and nano copper in PEG-400 [9]. However, in spite of their potential utility, some difficulties still exist, such as expensive or toxic reagents. Therefore, the development of new, simple methods for the synthesis of 1-(4-(1H-imidazol-1-yl) phenyl)-1, 2-dihydronaptho [1, 2-e] [1, 3]-3-thione and 3-one derivatives are of main Importance and these compounds show their biological activities