SUNDAY,SEPTEMBER 13 TH 2009 63. Prognosis and comorbidities in COPD E502 A longitudinal study of the relationship between serial changes in BODE index, mortality and readmissions in patients with COPD Fanny W.S. Ko, Jenny Ngai, Alvin Tung, S.S. Ng, Kennneth Lai, David Hui. Dept of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, Hong Kong Introduction: This study assessed the relationship between serial changes in BODE index (a multidimensional grading index including Body mass index, Obstruction of the airway [FEV 1 ], Dyspnoea score [modified Medical Research Council {mMRC} questionnaire and Exercise capacity [6 min walk test]) and mortality and readmissions of COPD patients. Method: A prospective cohort study involving 307 (256 males) COPD patients (recruited during their admissions for acute exacerbations COPD [AECOPD]). Assessment of the BODE index was performed at 6 weeks (baseline), 6 months, 12 months, 18 months and 24 months post hospital discharge. Mortality and read- missions in the subsequent 3 years were recorded. All the patients were managed by usual care with no specific intervention. Results: The mean(SD) age, FEV 1 % predicted were 75.2(8.0)yrs, and 49.3(21.8) respectively. Over the 3 years, 31.6% died whereas 77.2% had at least 1 readmis- sion for AECOPD. Baseline BODE index was predictive of both the survival and readmissions to hospital for AECOPD by Cox regression analysis (p<0.001 for both survival and readmissions). Patients with higher BODE scores were at higher risk for death; the hazard ratio for death from any cause per one-point increase in the BODE score was 1.30 (95% CI, 1.21-1.41; P<0.001). With usual care, 74 (24.1%), 116 (37.8%), 17 (5.5%) patients had increase (>1point), no change, and decrease in BODE (>1point) index over 24 months respectively. Serial changes in BODE index were not associated with both mortality and readmissions. Conclusion: Baseline BODE index could predict both survival and readmissions for AECOPD, whereas serial BODE index could not. E503 Comorbidities and disease specific health status in young and old COPD patients Alexandru Corlateanu 1 , Janwillem Kocks 2 , Thys Van Der Molen 2 , Victor Botnaru 1 . 1 Department of Internal Medicine N.1, State Medical and Pharmaceutical University Nicolae Testemitanu, Chishinau, Republic of Moldova; 2 University Medical Center Groningen, University of Groningen, Groningen, Netherlands COPD is an important cause of morbidity and disability in elderly and is often accompanied with other chronic diseases. These comorbid diseases might influence scores on COPD health status questionnaires. Aim: The aim of this study was to evaluate the relationship between comorbidities and disease specific health status in patients with COPD. Methods: Consecutive COPD patients visiting an out-patient clinic were evaluated by spirometry, BODE, and health status using the CCQ and the SGRQ. Comor- bidities were assessed by the Charlson Comorbidity Index (CCI) and the Chronic Disease Score (CDS). Young COPD patients Elderly COPD patients p n=78 n=80 Mean Std. Dev. Mean Std. Dev. Age 56 3.9 72 4.8 <0.001 FEV1%pred 42.7 14.4 42.3 12.8 0.87 MRC 3.4 0.8 3.8 0.7 <0.001 Charlson 2 1.3 2.8 1.3 <0.001 CDS 3.5 2.3 5 2.1 <0.001 SGRQ Total 59.4 11.6 68.6 12.8 <0.0001 CCQ Total 2.9 0.9 3.2 0.6 0.015 BODE 5.6 2.2 7 1.6 <0.001 67s Abstract printing supported by Chiesi Farmaceutici SpA. Visit Chiesi Farmaceutici SpA. at Stand B.40 E-Communication Session Room C9c - 10:45-12:45