Life Science Journal 2012;9(3) http://www.lifesciencesite.com http://www.lifesciencesite.com lifesciencej@gmail.com 1175 General Health Variations, in patients with MI, Longitudinal Case-Control Nested Design Study. Mohsen Momeninejad 1 , Hamid Reza Ghaffarian Shirazi 1, 2 , Bahman Sharifi 1 , Yasaman Ghafarian Shirazi 3 , Mohammad Malkzadh 1 , Nazir Hashemi 1 , Rahim Ostovar 1 , Farzad Karimpour 1,3 , Masood Moghimi 1 . 1. Social Determinants of Health Research Center, Yasuj University of Medical Sciences. Yasuj, I.R.Iran 2. School of Public Health, Tehran University of Medical Sciences.Tehran, I.R.Iran. 3- MA, English literature, Yerevan linguistic University von after Brusov, Yerevan, Armenia. 4. Institute of Biotechnology NASA (National Academy of sciences of Armenia), Yerevan, Armenia gshr3@yahoo.com Abstract: Studying the status of general heath in patients suffering from heart failure is crucially important taking the increasing prevalence of this disease and its impacts on total lifestyle of the patient and his/her family. This study aims at comparing the general health of patients with acute heart failure with control group during the outbreak of failure and three months after the failure. This study was conducted based on a linear case-study comprising subjects of control and den-like respondents over 83 patients suffering from heart failure and 83 people as the accompanies or neighbors of patient who are consistent with him/her in terms of gender and age were selected as the control group. From the beginning of patient’s admission and three months later, they were studied with the GHQ28 Standard questionnaire. The data was analyzed using SPSS software and the core indices, scatter and student x 2 and t tests. 78 percent of patients and 22 percent of control group had difficulties with respect to general health. The general health of patients had a significant difference in the beginning and three months later. However, this difference was not significant in the controls. During three months follow up, the patients had a lower general heath in comparison with the control group. This difference increased after three months. The probability of incidence of heart failure in patients having general health problem was 4.85 times more than other individuals. General health problems are considered as the effective risk factors for the incidence of heart failure and exacerbating it. It is necessary to take the trainings about how to control mental pressures and promotion of general health into consideration in order to prevent from MI and also its better recovery. [Momeninejad M, Ghaffarian Shirazi H.R.,Sharifi B, Ghafarian Shirazi Y, Malkzadh M, Hashemi N, Ostovar R, Karimpour F, Moghimi M. General Health Variations, in Patients with MI, Longitudinal Case-Control Nested design study. Life Sci J 2012;9(3):1175-1179]. (ISSN: 1097-8135). http://www.lifesciencesite.com . 164 Keywords: Heart, MI, General Health, Risk factors, Relative Risk. 1. Introduction Cardiovascular diseases are amongst the most common mortality reasons in the majority of the world’s countries; more than 30 percent of fatalities happen in the industrial countries of the world caused by these types of diseases. Studying general health conditions of the patients suffering from heart failure has a high significance considering the increasing prevalence of this disease and its impacts on the patient’s lifestyle and his/her family. The person affected by this disease may be faced with total changes in his/her family relations, job, values, physical and social ability and also his/her own self care; namely, his/her general health will deteriorate ( 1). The cardiovascular diseases not only have included a high rate of mortality, it has also brought about some constraints in the long-term in people’s lives due to having a disabling nature accompanied by developing some disorders in patient’s general health and also it will result in patient’s shorter lifetime(2). According to report given by World Health Organization in 1996, it has included around 20 percent of the mortality reasons and this amount reaches 50 percent of the total mortalities rate in developing countries. The American Heart Association also estimates that about half of the people who survive are fired from their works because of having a low level of general health and they impose the maximum possible medical costs to their societies(3). Conducting a study with the objective of determining the clinical results of general health improvement resulting from lifestyle moderation program in patients suffering from arteriosclerosis, Rutledge et al. demonstrated that taking part in the lifestyle change program which includes exercise, pharmacotherapy, consultation and diet and stress reduction techniques play a highly major role in reducing weight, increasing capacity for exercising and reducing risk factor and enhancement of the satisfaction level in the patients(4). In Iran, the total rate of mortality caused by heart failure has exceeded from 24.4 percent in 1979 to 38 percent in 1990. The majority of the deceased have died with the incidence of the first heart failure and/or with the second failures during the first 28 days after the attacks (5). Reducing the age of death caused by