Shi et al Diet Induced Endothelial Senescence in Baboons 1 Title page Title: Endothelial Senescence after High Cholesterol High Fat Diet Challenge in Baboons Short title: Shi et al Diet Induced Endothelial Senescence in Baboons Qiang Shi 1,2 , Gene B. Hubbard 2 , Rampratap S. Kushwaha 3 , David Rainwater 1 , Charles A. Thomas III 5 , M. Michelle Leland 2 , John L. VandeBerg 1, 2 , Xing L. Wang 2,4 1 Department of Genetics, 3 Department of Physiology and Medicine, Southwest Foundation for Biomedical Research; 2 Southwest National Primate Research Center, San Antonio, Texas; 4 Cardiothoracic Research Laboratory, Texas Heart Institute, St. Luke’s Episcopal Hospital, Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, Texas; 5 Department of Medicine/Division of Hematology, University of Texas Health Science Center, San Antonio, Texas Corresponding Author: Xing Li Wang, BCM390, One Baylor Plaza, Houston, TX 77030, Tel: 832-355-9939, Fax: 832- 355-9951; Email: xlwang@bcm.tmc.edu Page 1 of 29 Copyright Information Articles in PresS. Am J Physiol Heart Circ Physiol (February 2, 2007). doi:10.1152/ajpheart.01405.2006 Copyright © 2007 by the American Physiological Society.