AL-Qadisiya Journal of Vet. Med. Sci. Vol. 15 No. 1 2016 1 Effect of some feed additives against toxicity induced by aflatoxin contaminated diet in broiler Shaimaa Abdulradha Makki Alaa AbdulAziz Abed Coll. of Vet. Med. / Univ. of Al-Qadisiya email: alla.abd @qu.edu.iq (Received 8 February 2015, Accepted 25 March 2015) Abstract The effects of the Saccharomyces cerevisiae (SC) and Fructooligosaccharide (FOS) on body weight, feed conversion, body weight gain and immune response was investigated in broiler fed on aflatoxin (AF). A total number of 180 one day old broiler chickens (Hubbard classic) were randomly distributed into 6 experimental groups; G1: control (basal diet), G2: (basal diet + SC 2%), G3: (basal diet + FOS 0.25%), G4: (basal diet + AF100μg(, G5: (basal diet + AF100μg + SC 2%), G6: (basal diet + AF100μg + FOS 0.25). The weight range, feed conversion, body weight gain and humoral immunity of birds were evaluated. Results of (G2) and (G3) show a significant (P<0.05) increase weight range, body weight gain, fed conversion ratio and the antibody titers in compare to control, while the AF contaminated diet (G4) showed decrease in body weight gain, feed conversion ratio and the antibody titers against Newcastle disease virus. Aflatoxin groups treated with 2% Saccharomyces cerevisiae (G5) and 0.25% fructooligosaccharide (G6) show increased in the broilers performance value and humoral immune response of broilers vaccinated against Newcastle virus disease as compared to the aflatoxin group (G4). In conclusion the addition of Saccharomyces cerevisiae and fructooligosaccharide had a beneficial effects on broilers health and can minimize the effect of aflatoxin on broiler performance and immunity. Key words: Aflatoxin, broiler, feed additives, Probiotic, prebiotic. ΔاسέΩ ن فيأفاتوكسي باΙΪحΘ المسϢسمΘ الΪ ضΔائيά الغΕإضافا بعض اή تأثي ϢحϠوج الή ففϠ ع ءΎϤϴ شΪΒ عΎضήϟ اϲϜϣ ΪΒ عΰϳΰعϟ اΪΒ عاء ع ΔϴسΩΎقϟ اΔعϣΎΟ / ϱήτϴΒϟ اΐτϟ اΔϴϠ ك ΔاصΨ ال ϯήΟ ΔاسέΩ ήϴΛأΗ ϝΪعϣ ϰϠ عίϮΘكήفϟ اήϜ سϭ ΓήϴϤΨϟ اΔفΎ اضϭ ϥίϮϟ اΔΑΎΠΘاساϭ ΔϴϧίϮϟ اΓΩΎϳΰϟاϭ ϲائάغϟ اϞϳϮحΘϟ ا ΔاسέΩ عϣ ΔϴعΎϨϤϟ اήϴΛأΗ Νϭή فϰϠ عϦϴكسϮΗفاا اϡϮϤسΑ ΔقϴϠعϟ اΙϮϠΗ ϥϭΪΑ ϭع اϣ ΎϬϴϠك عΗϮϳΎΒϳήΒϟاϭ كΗϮϳΎΑϭήΒϟ اΔفΎ اض اΔϴΑήΗ ϢΗ Κϴ حϢحϟ 180 ϭ Ϊاحϭ ϡϮϳ ήϤعΑ Δخή فϰϟ اΎϴائϮ عشΎϬϤϴقسΗ ϢΗ 6 ΕاϣΎعϣ ؛ϰϟϭا اΔϠϣΎعϤϟ ا( G1 Η ) ΔعϮϤΠϣ ϞΜϤ ΔϴسΎاس اΔقϴϠعϟ اΖϟϭΎϨΗ Γήτϴسϟ ا, ( ΔϴϧΎΜϟ اΔϠϣΎعϤϟ اG2 ) ΔϴسΎاس اΔقϴϠعϟ اΖϟϭΎϨΗ + 2 , ΓήϴϤΨϟ اϦϣ % ΔΜϟΎΜϟ اΔϠϣΎعϤϟ ا ( G3 ΔϴسΎاس اΔقϠعϟ اΖϟϭΎϨΗ ) + 0,20 ϟ اήϜسϟ اϦϣ % ΪعقϤ , ( ΔعΑاήϟ اΔϠϣΎعϤϟ اG4 + ΔϴسΎاس اΔقϴϠعϟ اΖϟϭΎϨΗ ) 100 ϢغϭήϜϳΎϣ / فاا اϢ كغϦϴكسϮΗ , ( ΔسϣΎΨϟ اΔϠϣΎعϤϟ اG5 + ΔϴسΎاس اΔقϴϠعϟ اΖϟϭΎϨΗ ) 2 ΓήϴϤΨϟ اϦϣ % + 100 فاا اϢ/كغϢغϭήϜϳΎϣ ϦϴكسϮΗ , ( ΔسΩΎسϟ اΔϠϣΎعϤϟ اG6 ) ΔϴسΎاس اΔقϠعϟ اΖϟϭΎϨΗ + 0,20 ϱΩΎاح اήϜسϟ اϦϣ % + 100 فاا اϢ/كغϢغϭήϜϳΎϣ ϦϴكسϮΗ , αΎϴ قϢΗ ϥاίϭا اϝΪعϣ ϭ ϣ ϲائάغϟ اϞϳϮحΘϟ اϝΪ ع, .ΔϴϠμϤϟ اΔعΎϨϤϟاϭ ΔϴϧίϮϟ اΓΩΎϳΰϟ ا ΕήϬυ ا نتائجΔϠϣΎعϤϟ اΔعΑاήϟ اϲ فνΎفΨϧ اϭ ϥاίϭا اϝΪعϣ ϲائάغϟ اϞϳϮحΘϟ اϝΪعϣ , ΔϴϧίϮϟ اΓΩΎϳΰϟ ا, ϡΎسΟا اϝΪعϣϭ ϞسΎكϮϴϨϟ اνήϤϟ ΓΩΎضϤϟ اΔϧέΎقϤϟΎΑ عϣ ΔعϮϤΠϣ Γήτϴسϟ ا( G1 ) . ΕήϬυ اϲ فϱϮϨعϣ عΎفΗέ اΔΜϟΎΜϟاϭ ΔϴϧΎΜϟ اΔϠϣΎعϤϟ اΞئΎΘϧ ϝΪعϣ ϭ ϥاίϭا اϲائάغϟ اϞϳϮحΘϟ ا, ΔعϮϤΠϣ عϣ ΔϧέΎقϤϟΎΑ ϞسΎكϮϴϨϟ اνήϤϟ ΓΩΎضϤϟ اϡΎسΟا اϝΪعϣϭ ΔϴϧίϮϟ اΓΩΎϳΰϟ ا Γήτϴسϟ ا, Ώ ΎϬΘΠϟΎعϣ ϢΗ ϲΘϟ اϱήτفϟ اϢسϟ اϲΘϠϣΎعϣ 2 ϭ ΓήϴϤΨϟ اϦϣ % 0,20 ϟ اήϜسϟ اϦϣ % ΪعقϤ ( G5 ) (ϭ G6 ) ΕήϬυ ا , ϲائάغϟ اϞϳϮحΘϟ اϝΪعϣ ϲ فϱϮϨعϣ عΎفΗέ ا اΓΩΎϳΰϟ اΔϠϣΎعϤϟع اϣ ΔϧέΎقϤϟΎΑ ϞسΎكϮϴϨϟ اνήϤϟ ΓΩΎضϤϟ اϡΎسΟا اϝΪعϣϭ ΔϴϧίϮϟ .ΔعΑاήϟ اΞΘϨΘسϧ ΔفΎ اضϥ اΔاسέΪϟ اϦϣ 2 ϭ ΓήϴϤΨϟ اϦϣ % 0,20 ϟ اήϜسϟ اϦϣ % ϱίϮΘكή فΎϬϟ ϥϮϜϳ Ϊ قΕاήϴΛأΗ ΔϴΑΎΠϳ ا ϰϠ عΔϴفعϧϭ اءΩ أϢحϠϟ اΝϭή فϥ اϦϜϤϳ Η ϰϟ اϱΩ ؤϟ اϞϴϠقΘ Ϧϣ ΕاήϴΛأΘϟ ا.ϢحϠϟ اΝϭή فϰϠ عϱήτفϟ اϢسϟا اάϬϟ ΔϴΒϠسϟ ا :ΔاحيΘ المفΕماϠ الكيή الفطϡ السمو, ϢحϠوج الή ف, Δائيά الغΕضافاا ا, الوي , الحيίΰ معويبق الحيلسا ا.