Available Online at www.jbpr.in Journal of Biomedical and Pharmaceutical Research, Volume 3, Issue 4, 2014, 48-50 *Corresponding author: Amit Kumar | Page48 Page48 Page48 Page48 REVIEW ARTICLE ISSN: 2279 - 0594 CISPLATIN – A CHOICE OF DRUG FOR METASTATIC NON-SEMINOMATOUS GERM CELL CARCINOMA Amit Kumar 1 * , Girendra Gautam 2, Umesh Dakhad 3 , Ashish Kumar Mishra 4* 1 M.Pharm. Research Scholar, Bhagwant Institute of Pharmacy, M. Nagar, (U.P), India 2 Professor, Bhagwant Institute of Pharmacy, M. Nagar, (U.P) India 3 Associate Professor, Bhagwant Institute of Pharmacy,M. Nagar.(U.P) India 4 M.Pharm.Research Scholar, Bhagwant Institute of Pharmacy, M. Nagar,(U.P),India Received 21 June 2014; Accepted 3 July 2014 INTRODUCTION: What is Neoplasm? Cancer starts when the cells of an organ or tissue in the body become abnormal. They grow and multiply out of control. Normal cells have a life cycle. They reproduce themselves throughout the body to replace worn out tissue, to heal wounds and to maintain healthy organs. When something happens and cells grow out of control they usually form a mass, called a tumour. Some tumours grow only at the site where they begin (locally). These are called benign tumours. Other tumours grow locally but they might also invade and destroy the normal tissue around them or they might spread to distant parts of the body. These tumours are called malignant tumours or cancers. Sometimes malignant cells break loose from the original (primary) tumour, get carried to other parts of the body and start growing in the new site as an independent secondary cancer. A tumour that has spread in this way has ‘metastasized’ and the secondary tumour (or tumours) is called a metastasis (or metastases). Germ cell tumor: A Germ cell tumor (GCT): is a neoplasm derived from germ cells. Germ cell tumors can be cancerous or non-cancerous tumors. Germ cells normally occur inside the gonads (ovary and testis). Germ cell tumors that originate outside the gonads may be birth defects resulting from errors during development of the embryo. Description: Cisplatin Injection (cisplatin injection (cisplatin (cisplatin injection) injection) ) is a sterile aqueous solution, available in 50, 100 and 200 ml multiple dose vials, each mL containing 1 mg of cisplatin (cisplatin injection) and 9 mg sodium chloride in water for injection. HCI and/or sodium hydroxide added to adjust pH to 3.5 to 4.5. Cisplatin (cisplatin injection) (cis-diamminedi chloro- platinum) is a heavy metal complex containing a central atom of platinum surrounded by two chloride atoms and two ammonia molecules in the cis position. It is a white powder with the molecular formula PtCl 2 H 6 N 2 , and a molecular weight of 300.05. It is soluble in water or saline at 1 mg/mL and in dimethylformamide at 24 mg/mL. It has a melting point of 207°C. ABSTRACT Cisplatin is a type of Medical Treatment Called Chemotherapy. The Purpose of Chemotherapy to Kill Cancer Cell or Prevent the growth. Cancer starts when the cells of an organ or tissue in the body become abnormal. They grow and multiply out of control. Normal cells have a life cycle. They reproduce themselves throughout the body to replace worn out tissue, to heal wounds and to maintain healthy organs. When something happens and cells grow out of control they usually form a mass, called a tumour. Key words: Cisplatin, Neoplastic drug, Germ cell tumor