1 Caspase-1-independent maturation of IL-1 in Ischemic Brain Injury: is there a role for gelatinases? Diana Amantea 1* , Rossella Russo 1 , Michelangelo Certo 1 , Laura Rombolà 1 , Annagrazia Adornetto 1 , Luigi A. Morrone 1,2 , Maria Tiziana Corasaniti 3 , Giacinto Bagetta 1,2 1 Section of Preclinical and Translational Pharmacology, Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, Italy; 2 University Consortium for Adaptive Disorders and Head Pain (UCADH), Section of Neuropharmacology of Normal and Pathological Neuronal Plasticity, University of Calabria, Italy; 3 Department of Health Sciences, University Magna Graecia of Catanzaro, Italy. Running title: IL-1 in Ischemic Brain Injury * Corresponding author: Diana Amantea, Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, via P. Bucci, ed. Polifunzionale, 87036, Rende (CS), Italy; tel. +39-0984-493189; email: amantea@unical.it