American Journal of Animal and Veterinary Sciences 6 (2): 77-79, 2011 ISSN 1557-4555 © 2011 Science Publications Corresponding Author: Garedaghi Yagoob, Department of Pathobiology, Tabriz Branch, Islamic Azad University, Tabriz, Iran Tel: 00989143110499 77 Effect of Triclabendazole and Levamisole on Experimental Hydatic Cyst in Rat 1 Garedaghi Yagoob, 2 Khayatnouri Mirhadi, 3 Sadeghi Peyman and 4 Safarmashaei Saeid 1 Department of Pathobiology, 2 Department of Pharmacology, 3 Post Graduated Student of Veterinary Medicine, 4 Young Researchers Club, Tabriz Branch, Islamic Azad University, Tabriz, Iran Abstract: Problem statement: Hydatidosis has dispersed worldly and is one of the common dangerous diseases between human and animals and is found abundantly in areas that human, dogs and herbivorous are in close relationship. Approach: In this study, firstly, 32 rats were divided into two groups of control and case and 2000 protoscolices were injected into peritoneal hole. After two months, rats of case group were feed by drinkable 5 mL Triclabendazole + 3.41 mL Levamisole for 60 days. Then after 6 months of contamination period, rats of control group and case group killed by anesthetic drug then necropsy and guts inspection of hydatid cyst was implemented. Results: The results show that in livers of control group there are 2 cysts, in kidneys 9 cysts and in lungs 87 cases. Average of contamination in this group to hydatid cyst was 32.6 but in case group there were in liver on cyst, in kidneys 5 cysts and in lungs 63 cysts. Average of guts contamination to hydatid cyst in case group was 23. Conclusion: Analyzing results in case and control groups shows that Triclabendazole + Levamisole drugs effect was 30% that this amount is not sufficient for hydatid cyst treatment. Key words: Hydatid cyst, hydatic fluid, hydatic sand, flatworm echinococcus, cosmopolitan distribution, hydatid disease, peritoneal hole, occupying lesions, antihelminthic chemotherapy, latex agglutination INTRODUCTION Species under genus Echinococcus are small tapeworms of carnivores with larval (metacestode) stages known as hydatid proliferating asexually in various mammals including humans (Xiao et al., 2005; 2006). Hydatid cyst has a worldwide distribution and has been recognized since ancient times (Gulam et al., 2002). Human hydatidosis is a parasitic infection of the liver and other organs caused by the flatworm Echinococcus, most commonly E. granulosus which is a 5 mm long hermaphroditic tapeworm that has dog, foxes or coyotes as the definitive host and sheep, swine, cattle and zebra as the intermediate host. Hydatidosis is a cyclozoonotic infection of cosmopolitan distribution (Morris and Richards, 1992; Gossios et al., 1997). It is one of the main forms of parasitic disease in farm animals caused by the larval stage of Echinococcus tape worms which utilize canines as definitive host and various herbivores or rodent as intermediate host. These cysts are characterized by cystic space occupying lesions in the liver, the lungs and rarely in other parts of the body (Dhaliwal and Kalkat, 1997; Halilolu et al., 1997; Topcu et al., 2000; Ghaly, 2009). Therefore the aim of present study was to determine the effect of Triclabendazole on experimental hydatic cyst in rat. MATERIALS AND METHODS In this study, firstly, 32 rats were divided into two groups of control and case and 2000 protoscolices were injected into peritoneal hole. After two months, rats of case group were feed by drinkable 5 mL Triclabendazole +3.41 mL Levamisole for 60 days. Then after 6 months of contamination period, rats of control group and case group killed by anesthetic drug