Variants in Interferon-α Pathway Genes and Response to Pegylated-Interferon-α2a plus Ribavirin for Treatment of Chronic HCV Infection in the HALT-C Trial Tania Mara Welzel 1 , Timothy R. Morgan 2 , Herbert L. Bonkovsky 3 , Deepa Naishadham 4 , Ruth M. Pfeiffer 1 , Elizabeth C. Wright 5 , Amy A. Hutchinson 6 , Andrew T. Crenshaw 6 , Arman Bashirova 7 , Mary Carrington 8 , Myhanh Dotrang 9 , Richard K. Sterling 10 , Karen L. Lindsay 11 , Robert J. Fontana 12 , William M. Lee 13 , Adrian M. Di Bisceglie 14 , Marc G. Ghany 15 , David R. Gretch 16 , Stephen J. Chanock 1,6 , Raymond T. Chung 17 , Thomas R. O’Brien 1,* , and the HALT-C Trial Group 1 Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 2 Division of Gastroenterology, University of California - Irvine, Irvine, CA and Gastroenterology Service, VA Long Beach Healthcare System, Long Beach, CA 3 Departments of Medicine and The Liver-Biliary-Pancreatic Center, University of Connecticut Health Center, Farmington, CT and Carolinas Medical Center, Charlotte, NC 4 New England Research Institutes, Watertown, MA * Corresponding author, Mailing Address: 6120 Executive Blvd., Room 6111, Rockville, MD 20852. This is publication #32 of the HALT-C Trial. In addition to the authors of this manuscript, the following individuals were instrumental in the planning, conduct and/or care of patients enrolled in this study at each of the participating institutions as follows: University of Massachusetts Medical Center, Worcester, MA: (Contract N01-DK-9-2326) Gyongyi Szabo, MD, Maureen Cormier, RN, Donna Giansiracusa, RN University of Connecticut Health Center, Farmington, CT: (Grant M01RR-06192) Michelle Kelley, RN, ANP Saint Louis University School of Medicine, St Louis, MO: (Contract N01-DK-9-2324) Bruce Bacon, MD, Brent Neuschwander-Tetri, MD, Debra King, RN Massachusetts General Hospital, Boston, MA: (Contract N01-DK-9-2319, Grant M01RR-01066), Jules L. Dienstag, MD, Andrea E. Reid, MD, Wallis A Molchen, Loriana Di Giammarino University of Colorado School of Medicine, Denver, CO: (Contract N01-DK-9-2327, Grant M01RR-00051) Gregory T. Everson, MD, Jennifer DeSanto, RN, Carol McKinley, RN University of California - Irvine, Irvine, CA: (Contract N01-DK-9-2320, Grant M01RR-00827) John C. Hoefs, MD, M. Mazen Jamal, MD, MPH, Choon Park, RN University of Texas Southwestern Medical Center, Dallas, TX: (Contract N01-DK-9-2321, Grant M01RR-00633) Janel Shelton, Rivka Elbein, RN, BSN University of Southern California, Los Angeles, CA: (Contract N01-DK-9-2325, Grant M01RR-00043) Carol B. Jones, RN, Susan L. Milstein, RN University of Michigan Medical Center, Ann Arbor, MI: (Contract N01-DK-9-2323, Grant M01RR-00042) Anna S.F. Lok, MD, Pamela A. Richtmyer, LPN, CCRC Virginia Commonwealth University Health System, Richmond, VA: (Contract N01-DK-9-2322, Grant M01RR-00065) Mitchell L. Shiffman, MD, Charlotte Hofmann, RN, Paula Smith, RN National Institute of Diabetes and Digestive and Kidney Diseases, Liver Disease Branch, Bethesda, MD: T. Jake Liang, MD, Yoon Park, RN, Elenita Rivera, RN, Vanessa Haynes-Williams, RN National Institute of Diabetes and Digestive and Kidney Diseases, Division of Digestive Diseases and Nutrition, Bethesda, MD: Leonard B. Seeff, MD, Patricia R. Robuck, PhD, Jay H. Hoofnagle, MD University of Washington, Seattle, WA: (Contract N01-DK-9-2318), Chihiro Morishima, MD, Minjun Chung Apodaca, BS, ASCP New England Research Institutes, Watertown, MA: (Contract N01-DK-9-2328) Kristin K Snow, Sc.D., Teresa M. Curto, MPH, Linda J. Massey Armed Forces Institute of Pathology, Washington, DC: Zachary D Goodman, MD Data and Safety Monitoring Board Members: (Chair) Gary L. Davis, MD, Guadalupe Garcia-Tsao, MD, Michael Kutner, PhD, Stanley M. Lemon, MD, Robert P. Perrillo, MD NIH Public Access Author Manuscript Hepatology. Author manuscript; available in PMC 2010 June 1. Published in final edited form as: Hepatology. 2009 June ; 49(6): 1847–1858. doi:10.1002/hep.22877. NIH-PA Author Manuscript NIH-PA Author Manuscript NIH-PA Author Manuscript