World Journal of Fish and Marine Sciences 7 (4): 325-333, 2015 ISSN 2078-4589 © IDOSI Publications, 2015 DOI: 10.5829/idosi.wjfms.2015.7.4.96230 Corresponding Author: Amira A.Z. Omer, Department of Fish Diseases and Management, Faculty of Veterinary Medicine, Kafr El-Sheikh University, Egypt. Tel: +01020517904, E-mail: amira_vet2007@yahoo.com. 325 Role of Some Herbs in Controlling Aflatoxicosis in Cultured Oreochromis niloticus Mohamed M.A. Zayed, Riad H. Khalil, Talaat T. Saad and Amira A.Z. Omer 1 2 2 3 Department of Fish Diseases, Animal Health Research Institute Kafr El-Sheikh Branch, Egypt 1 Department of Poultry and Fish Disease, Faculty of Veterinary Medicine, Alexandria University, Egypt 2 Department of Fish Diseases and Management, 3 Faculty of Veterinary Medicine, Kafr El-Sheikh University, Egypt Abstract: The present study provides that the black seed is the best herbs that decrease the aflatoxin effect in cultured Oreochromis niloticus followed by garlic and onion, respectively. The results showed that level of RBCs and WBCs, differential leucocytic counts and phagocytosis process improved with addition of black seed, garlic and onion. The residue of aflatoxin in fish flesh decreased in the groups treated with black seed, garlic and onion than the control or fish fed on the aflatoxin. The results proved that, frequent supplementation of fish ration with black seed, garlic and onion can reduce the aflatoxin hazards in the fish. Also the economic efficiency measures (total return, total costs, net profit, total returns/total costs and net return to total costs) improved in the groups fed with black seed, garlic and onion and when all of them added to the fish treated with aflatoxin diet improved economic efficiency results than the group treated with aflatoxin only. Key words: Economic Efficiency Black Seed Aflatoxin INTRODUCTION aflatoxin. Both Ginseng extract and Nigella sativa Oil 1% The using of synthetic drugs in the therapeutic field Nigella sativa showed more improvement of all enzymes may have adverse effects which may be more dangerous of kidney and liver and also total lipid and cholesterol than the disease itself by Fluk et al. [1], from this fact and were reduced and body weight increased with with the call of “Back to nature” medical plants consider improvement of economic and productive efficiency of an important target area for several studies to show fish production farms. The green onion has antifungal possibility of its use in a variety of health problems. activity on A. parasiticus that producing aflatoxin and has The garlic has antiviral, antibacterial, antifungal and carceingenic effect on the human, according to Kim [3]. So antiparasitic effect. Garlic is nicknamed Russian penicillin this study was carried-out to throw the light on using the for its widespread use as a topical and systemic natural feeds on the improving immunity of the fish antimicrobial agent. Allicin has antimicrobial effects Oreochromis niloticus and its role in the prevention of in vitro against many viruses, bacteria, fungi and Aflatoxicosis in the fish through study the effect of black parasites, but dried, powdered and oil preparations of seed (Nagilla sativa), garlic and onion on the number of garlic have not been shown to have significant RBCs, WBCs and its differentials, Phagocytic activity and antimicrobial activity. Also, it has antifungal effect, thus phagocytic index as well as their effect on the residues of Garlic enjoys a worldwide reputation as an antifungal the Aflatoxin in fish flesh. folk remedy. Mona et al. [2], reported that, Aflatoxin the major toxic metabolites of fungi which are able to MATERIALS AND METHODS induce chronic liver damages. The antioxidant and hepatoprotective effects of Ginseng extract and Nigella A total number of 240 healthy Nile Tilapia sativa Oil 1% on Aflatoxin was investigated. Moreover (Oreochromis niloticus) were collected from Barseek fish the liver exhibited some clinico-pathological changes and farm at Behera Governorate. Fish were transported alive decreased body weight due to the toxic effects of to the laboratory in plastic bags containing water reduced the development of hepatotoxicity by Aflatoxin.