IJPRD, 2011; Vol 3(8): November 2011 (184 - 189) International Standard Serial Number 0974 – 9446 Available online on www.ijprd.com 184 ---------------------------------------------------------------------------------------------------------------------------------------------------------------- DEVELOPMENT AND OPTIMIZATION OF FAMOTIDINE GASTRORETENTIVE DRUG DELIVERY SYSTEM Bharati V. Bakde 1 *, Madhuri Channawar 1 , Anil V. Chandewar 1 , B. Mishra 2 1 Pataldhamal Wadhwani College of Pharmacy Yavatmal -442001, India 2 Banaras Hindu University, Varanasi, UP, India ABSTRACT Famotidine (FMT) gastroretentive (GR) controlled release system was formulated to increase gastric residence time leading to improved drug bioavailability. Novel combinations of carbopol 940 P, Psyllium Husk, Rosin and Eudragit RLPO were selected for the present study. Floating lag time (Flag) and diffusion exponent as dependent variables revealed that the amount of carbopol 940 P, Psyllium Husk, Rosin, Eudragit RLPO have a significant effect (p < 0.05) on famotidine release and Flag. FMTGR tablets were prepared and evaluated for mass, thickness, hardness, friability, drug content and floating property. Tablets were studied for dissolution for 12 h and exhibited controlled release of FMT with floating for 12 h. The release profile of the optimized batch C9 fitted zero- -order kinetics (R 2 = 0.954). Correspondence to Author Bharati V. Bakde Pataldhamal Wadhwani College of Pharmacy Yavatmal,, Maharashtra, India. Email bakdebharati@rediffmail.com Key Words Famotidine, gastroretention, floating tablets, release kinetics, controlled release