International Journal of Advanced Engineering Research and Science (IJAERS) [Vol-4, Issue-4, Apr- 2017] https://dx.doi.org/10.22161/ijaers.4.4.38 ISSN: 2349-6495(P) | 2456-1908(O) www.ijaers.com Page | 246 Susceptibility Gene Prediction in Hereditary Disease Retinoblastoma S. Sumathi 1 , Dr. R. Dhaya 2 , Dr. R. Kanthavel 3 1 Research Scholar, Velammal Engineering college, Chennai, India 2 Associate professor, Rajalakshmi Engineering College, Chennai, India 3 Vice Principal, Rajalakshmi, Institute of Technology, Chennai, India Abstract— Nowadays Bioinformatics, proteomics and Genomics are the most intriguing sciences to understand the human genome and diseases. Several hereditary genetic diseases like Retinoblastoma involve a sequence of complex interactions between multiple biological processes. With this paper, genetic similarities were found within a selected group of patient’s DNA sequences through the use of signal processing tools. DNA, RNA and protein sequences have similarities in structure and function of the gene with their location. In this paper, we introduce a novel method using scoring matrix and wavelet windowing, for the integrative gene prediction. The proposed methods not only integrate multiple genomic data but can be used to predict gene location, gene mutation and genetic disorder from the multi-block genomic data. The performance was assessed by simulation. Keywords— Gene, scoring matrix, WWM. I. INTRODUCTION Retinoblastoma is a malignant cancer of the increasing retinal cells caused in the majority cases by mutations in both copies of the RB1 gene. The RB1 gene is a tumor suppressor gene, located on the genetic material, chromosome 13q14 and is the first cloned human cancer gene. The gene codes for the tumor suppressor protein pRB, which by binding to the transcription factor E2F, inhibits the cell from entering the S-phase during mitosis. Latest facts about retinoblastoma suggests that post-mitotic cone precursors are uniquely sensitive to pRB depletion and may be the cells in which retinoblastoma originates. The occurrence and viability of retinoblastic cells may be more complex than suggested by simple loss of function of the RB1 alleles. Hereditary retinoblastoma demonstrate close relation of the gene for this cancer with genetic locus for esterase D. Data are presented here in support of the hypothesis that at least one disease, the retinoblastoma observed in children is caused by two mutational events. Fig.1: Healthy eye Fig.2: Retinoblastoma affected eye Fig.3: Flow graph of gene mutation in Eye