Accepted Manuscript Title: Structure and dynamics of the insulin receptor: implications for receptor activation and drug discovery Authors: Libin Ye, Suvrajit Maji, Narinder Sanghera, Piraveen Gopalasingam, Evgeniy Gorbunov, Sergey Tarasov, Oleg Epstein, Judith Klein-Seetharaman PII: S1359-6446(17)30187-3 DOI: http://dx.doi.org/doi:10.1016/j.drudis.2017.04.011 Reference: DRUDIS 2008 To appear in: Please cite this article as: Ye, Libin, Maji, Suvrajit, Sanghera, Narinder, Gopalasingam, Piraveen, Gorbunov, Evgeniy, Tarasov, Sergey, Epstein, Oleg, Klein-Seetharaman, Judith, Structure and dynamics of the insulin receptor: implications for receptor activation and drug discovery.Drug Discovery Today http://dx.doi.org/10.1016/j.drudis.2017.04.011 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.