JScholar Publishers Clinical Eicacy of Local Delivered Minocycline in the Treatment of Chronic Periodontitis Smoker Patients Nayer Aboelsaad 1,* , Rayan Ghandour 2 , Roula Abiad 3 1 Department of Oral Surgical Sciences, Faculty of Dentistry, Beirut Arab University, Lebanon, Sabbatical leave from Faculty of Dentistry, Mansoura University, Egypt. 2 Faculty of Dentistry, Beirut Arab University, Lebanon. 3 Assistant professor of Endodontics, Department of Restorative sciences, Faculty of Dentistry, Beirut Arab Univer- sity, Lebanon, P.O. Box 11-5020 Riad El Solh 11072809 - Beirut, Lebanon. Research Open Access *Corresponding author: Nayer Aboelsaad, Associate professor of Periodontology, Department of Oral Surgical Sci- ences, Faculty of Dentistry, Beirut Arab University, Lebanon, Sabbatical leave from Faculty of Dentistry, Mansoura University, Egypt, Email: naier74@gmail.com ©2013 he Authors. Published by the JScholar under the terms of the Crea- tive Commons Attribution License http://creativecommons.org/licenses/ by/3.0/, which permits unrestricted use, provided the original author and source are credited. J Dent Oral Health 2014 | Vol 2: 201 Journal of Dentistry and Oral Health Received Date: July 18, 2014; Accepted Date: September 24, 2014; Published Date: September 26, 2014 Citation: Nayer Aboelsaad, et al. (2014) Clinical Eicacy of Local Delivered Minocycline in the Treatment of Chronic Peri- odontitis Smoker Patients. J Dent Oral Health 1: 1-5 Abstract Aim: he aim of this study was to evaluate the eicacy of a locally delivered 2% minocycline as an adjunct to scaling and root planing plus oral hygiene measures in treating chronic periodontitis smoker patients. Materials and Methods: his was a randomized controlled trial using a split-mouth study design. Twenty pairs of sites in twenty smoker patients with similar deep probing depths were randomly allocated to test and control groups. he test sites received minocycline ater root debridement. he clinical parameters included the plaque index, probing pocket depths, at- tachment levels, and bleeding upon probing. hey were evaluated at the baseline, and ater 3 and 6 months. Results: Both the test and control sites showed statistically signiicant improvements in the clinical periodontal parameters over the baseline measurements during the study period (P<.05). In follow-up, the intervals sites that received minocycline showed more favorable results manifested by probing depth reduction. his improvement was constant at 3 and 6 months and the diference between the two groups was statistically signiicant (P<.05). Conclusion: he study results show that patient motivation to maintain meticulous oral hygiene self-care with adjunctive professional dental care using local delivery 2% minocycline can signiicantly enhance treatment outcome of deep periodon- tal pockets in chronic periodontitis smoker patients. Keywords: Minocycline; Local delivery; Smoking; Chronic periodontitis Introduction Local delivery of antimicrobial agents in treating periodonti- tis patients is becoming more prevalent since it leads to higher concentration of the drug at the intended site of action using a lower dose with an associated reduction in side efects relative to systemic administration [1,2]. However, despite many stud- ies in the periodontal literature on the local delivery concepts, surprisingly there are few studies that demonstrate the clinical eicacy using intra-pocket delivery systems [3-5]. Moreover, several studies have failed to show clinically important efects provided by the intra-pocket drug delivery systems when used as individual mono-therapy. Other studies have demonstrated that these systems have beneicial efects in terms of probing depth reduction; however, the statistical signiicance reached in these studies was not always clinically signiicant [6,7]. Smoking is known as a major risk factor for increasing the prevalence and severity of periodontal destruction. In gen- eral, studies have shown that smoking increases the risk for developing periodontal disease by two to ive folds, and these efects seem to be dose dependent. Also, smoking accelerates the progression of periodontitis and jeopardizes the healing