ISSN: 2320-5407 Int. J. Adv. Res. 5(4), 1872-1884 1872 Journal Homepage: - www.journalijar.com Article DOI: 10.21474/IJAR01/4025 DOI URL: http://dx.doi.org/10.21474/IJAR01/4025 RESEARCH ARTICLE THE EFFECT OF EZETIMIBE ON GLYCEMIC PARAMETER IN IRAQI WOMEN WITH METABOLIC SYNDROME. Ali K. Hushi Allami, Prof. Dr. Faruk H Al-Jawad, Asst. Prof. Yaseen O.Yaseen, M. Haider F. Shamukh Alsaedi. …………………………………………………………………………………………………….... Manuscript Info Abstract ……………………. ……………………………………………………………… Manuscript History Received: 16 February 2017 Final Accepted: 18 March 2017 Published: April 2017 Metabolic syndrome is multiple clinical component that leads development of Type 2 Diabetes Mellitus, atherosclerosis and various diseases. The study included 90 female with metabolic syndrome according to International Diabetic Federation (IDF) criteria. They divided into three groups (30 patients in each group) First group put on diet restriction and physical exercise, the second group put on metformin 750 mg extended release once daily while the third group given ezetimibe 10 mg tab plus diet restriction and physical exercise.The duration of study 12 weeks ,samples taken from each patients at zero time to determine baseline level and after 12 weeks including measurements of WC,BMI,FBS,FIHOMA-IRHbA1c ,TG and HDL. Results:- Show significant changes in the measured parameter in the first group while highly significant changes in ezetimibe and metformin group Conclusion:- From these noticeable changes in the patients taken ezetimibe we conclude that ezetimibe have effect in improving glycemic parameter in Iraqi metabolic syndrome women. Copy Right, IJAR, 2017,. All rights reserved. …………………………………………………………………………………………………….... Introduction:- The metabolic syndrome is a clustering of components including hyperglycemia/insulin resistance, obesity and dyslipidemia (Putnam, Shoemaker et al. 2012) . Metabolic syndrome also known as syndrome x, Reavansyndrome , insulin resistance syndrome andcrdiometabolic syndrome(Ninomiya, L’Italien et al. 2004). Historically In 1988, Gerald Reaven hypothesized that insulin resistance could be the underlying factor conjugating this constellation of abnormalities, which called “syndrome X (Das 2010). Metabolic syndrome was defined by different association and organization, firstlyThe World Health Organization (WHO) first was updated by the American Heart Association and the National Heart Lung and Blood Institute in 2005 (Villagra 2009) . European Group for the Study of Insulin Resistance( EGIR) in 2004 also put diagnostic criteria. In 2005, the International Diabetes Foundation (IDF) developed its definition in 1998(Kilpatrick, Rigby et al. 2007). WHO have certain criteria for the definition and diagnosis the patient to have metabolic syndrome. Corresponding Author:- M. Haider F. Shamukh Alsaedi.