Journal of the Nigerian Association of Mathematical Physics Volume 36, No. 2 (July, 2016), pp 305 – 310 © J. of NAMP Journal of the Nigerian Association of Mathematical Physics Volume 36, No. 2 (July, 2016), 305 – 310 305 INFLUENCE OF NANOPARTICLES AS DELIVERY AGENTS IN PHOTODYNAMIC THERAPY Abba Alhaji Bala 1 , Mukhtar Lawan Adam 2 , Sabiu Said Abdullahi 3 And Ibrahim Murtala Musa 4 1, 3, 4 Department of Physics, Federal University Dutse, P.M.B.7156 Jigawa State Nigeria 2 Department of Physics, Bayero University Kano, P.M.B. 3011 Kano State Nigeria To whom correspondence should be addressed; 1 Email: abkabuga@yahoo.com, 1 Mobile: +2348130709998 ABSTRACT This paper presents the influence of nanoparticles as the delivery agents in photodynamic therapy for clinical application to overcome variety of cutaneous and sub-cutaneous diseases including cancer due to their less toxicity, super paramagnetic behavior, high magnetization saturation, surface chemistry, stability, size and biocompatibility. Nanoparticles principles and molecular mechanism of action when incorporated with Photosensitizer (PS) has been discussed, whereby introducing the nanoparticles enhance effective treatment in PDT by targeting the cell membrane and deliver the singlet oxygen; which is a powerful oxidant that can react with several kinds of biomolecules, as well as prevent the PS from moving out of the cell by resistive multidrug mechanisms. Keywords: Photodynamic therapy, Nanoparticles, Drug Delivery. 1. INTRODUCTION Photodynamic therapy (PDT) is a modern approved treatment modality of many cancers that is believed to operate through cytotoxic singlet oxygen production when light is absorbed by a photosensitizer (PS) and transfer this energy to ground state oxygen from its excited triplet state. The production rate of singlet oxygen solemnly depends on PS absorption, fluence rate, PS concentration and triplet oxygen availability in the tissue. Moreover, high fluence rate accelerates photochemical conversion of triplet to singlet state depletion thereby regulating photodynamic process and tumor control [1]. Photodynamic therapy is of advantage to both the patient and the physician. The need for delicate surgery and lengthy recuperation periods is minimized, along with minimal formation of scar tissue and disfigurement. PDT uses selective irradiation in therapeutic treatment which does not damage tissues that are healthy. This mode of treating cancer is very fast, easy and causes no pain to the person under cure with least effect. It develops no resistance in case of repeated treatment. It can also be used to treat cancers that are resistance to other medication and heal very fast as the collagen contain in the tissue is not affected by photodynamic damage [2]. Base on these, photodynamic therapy appeared to be a promising way of transforming many of the existing problems in definitive cancer therapies with least effect. In PDT, light photosensitizing drug (photosensitizer), oxygen, and light are