IAJPS 2017, 4 (05), 1130-1135 Fahad Saleem et al ISSN 2349-7750 1130 www.iajps.com Page 1130 CODEN (USA): IAJPBB ISSN: 2349-7750 INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES http://doi.org/10.5281/zenodo.582319 Available online at: http://www.iajps.com Research Article EVALUATION OF ESSENTIAL ELEMENT LEVELS IN THALASSEMIA MAJOR PATIENTS OF QUETTA CITY, PAKISTAN Adeela Anwer 1 , Zahid Mehmood 1 , Khalid Mehmood 1 , Aashif Sajad 1 , Adeel Ahmed 2 and Fahad Saleem 2* 1 Institute of Biochemistry, University of Balochistan, Quetta 2 Faculty of Pharmacy & Health Sciences, University of Balochistan, Quetta Abstract: Objective: The aim of this study was to evaluate essential element levels in thalassemia major patients of Quetta city, Pakistan. Methods: A single cohort, observational based study design was adopted. Evaluation of some essential element levels in thalassemia major patients was investigated through flame photo meter, CBC analyzer and commercially available kits.. The investigations were conducted on 325 thalassemia major patients of both genders. Investigated data were arranged by SPSS v. 20 and consider significant when p values were <0.05. Results: Three hundred twenty five thalassemia major patients take part in study. One hundred and seventy five (53.8%) respondents were males in majority and maximum patients were from the age group of 6-10 years. In term of ethnic group, the maximum thalassemia major patients were Pathan (n= 92, 28.3%). Majority of thalassemia major patients had A+ blood group (28.6% and n= 93). Zinc (51.6144+7.22) showed maximum concentration of 66.79 mmol/L and minimum concentration of 37.30 mmol/L. Copper (147.66+9.13) had maximum concentration 160.12 mmol/L and minimum concentration of 106.72 mmol/L. Calcium (8.3499+0.171) was resulted with maximum concentration of 8.89 mmol/L and minimum concentration of 8.02 mmol/L. Chlorides (101.98+0.56) showed maximum concentration of 103.2 mmol/L and minimum concentration of 100.5 mmol/L while sodium (134.99+1.105) showed maximum concentration of 137.2 and minimum of 131.6 mmol/L. Potassium (4.7047+0.121) had maximum concentration of 4.95 mmol/L and minimum concentration of 4.00 mmol/L in this study. From CBC, the hemoglobin concentration was (6.52 + 1.16) and RBCs counts were (4.75 + 0.52) which had maximum concentration of 9.2 g/dL. Conclusion: The current study concluded that zinc and calcium concentration was low from normal range concentration, while copper, sodium and potassium levels were high from the normal level of these elements. Corresponding author: Fahad Saleemm, Faculty of Pharmacy & Health Sciences, University of Balochistan, Quetta. Please cite this article in press as Fahad Saleemm et al, Evaluation of Essential Element Levels in Thalassemia Major Patients of Quetta City, Pakistan, Indo Am. J. P. Sci, 2017; 4(05). QR code