International Journal of Hepatobiliary and Pancreatic Diseases, Vol. 4, 2014. Int J Hepatobiliary Pancreat Dis 2014;4:40–45. www.ijhpd.com Sanei et al. 40 Original article OPen acceSS Reduction of peritoneal adhesion bands by mycophenolate mofetil (CellCept) and prednisolone in rats Behnam Sanei, Mohsen Mahmoudieh, Parnian Shariati, Ehsan Zare Bidaki, Mohsen Mahmoudieh, Hamid Talebzade, Hamid Reza Jafari AbstrAct Aims: the purpose of this study was to assess the efficacy of prednisolone and cellcept in decreasing postoperative adhesion band formation in rats. Methods: sixty male rats were randomly divided into three equal groups. A standard midline incision was made on the abdomen of each rat, then 2 mL of 10% sterile solution talc was injected into intraperitoneal cavity in order to induce adhesion. Group 1 served as control group, while group 2 received oral cellcept (40 mg/kg/d) and group 3 received oral Prednisolone (5 mg/kg/d) for 4 weeks. results: the formation of adhesion bands in control group was significantly higher than the prednisolone and cellcept group (p <0.001). the amount of adhesion bands in the second group was similar to the third one. conclusion: Orally administered cellcept is as effective as oral prednisolone in declining chance of intraperitoneal adhesion band formation, although it causes fewer complications such as infection in rats. Keywords: Adhesion band, Mycophenolate Mofetil (cellcept), Prednisolone Behnam Sanei 1 , Mohsen Mahmoudieh 1 , Parnian Shariati 2 , Ehsan Zare Bidaki 3 , Hamid Talebzade 2 , Hamid Reza Jafari 4 Affiliations: 1 Assistant Professor, Department of Surgery, Isfahan University of Medical Sciences, Isfahan, Iran; 2 De- partment of Surgery, Isfahan University of Medical Scienc- es, Isfahan, Iran; 3 Department of Internal Medicine, Isfahan University of Medical Sciences, Isfahan, Iran; 4 Medical Stu- dent, Isfahan University of Medical Sciences, Isfahan, Iran. Corresponding Author: Dr. Parnian Shariati, Department of Surgery, Isfahan University of Medical Sciences, Isfahan, Iran; Email: p.shariati2000@gmail.com Received: 04 April 2014 Accepted: 09 May 2014 Published: 29 July 2014 How to cite this article Sanei B, Mahmoudieh M, Shariati P, Bidaki EZ, Talebzade H, Jafari HR. Reduction of peritoneal adhesion bands by mycophenolate mofetil (CellCept) and prednisolone in rats. Int J Hepatobiliary Pancreat Dis 2014;4:40–45. Article ID: 100019IJHPDGN2014 ********* doi:10.5348/ijhpd-2014-19-OA-7 iNtrODUctiON Peritoneal adhesions form pathological junctions between the omentum, small and large bowel, abdominal wall, and other intra-abdominal organs. These improper bonds vary from a thin layer of connective tissue to a thick fibrous bridge containing blood vessels and nerve tissue which thoroughly attach two organ surfaces [1–4]. Adhesion formation is a common complication of the abdominal surgery which happens in more than majority of patients after abdominal and colorectal surgeries [4, 5]. Small bowel obstruction (most overriding one), persistent pelvic pain, ectopic pregnancy, and infertility are some illustration of adhesion complications [4, 6, 7]. Moreover, about 6% of all re-admissions are in the correlation with adhesion formation and require further surgical intervention which the burden of such surgical interventions is dramatically increased [4, 8–10]. Thus, patients’ quality of life is unfortunately affected by adhesion-related problems. As anticipated, the high recurrence rate of small bowel adhesion-related obstruction followed by expensive medical management is a considerable issue in this matter [4, 11, 12]. Recently, no convenient method is established in order to prevent adhesion formation or recurrence [13].