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Canaloplasty for Pigmentary
Glaucoma With Coexisting
Conjunctival Lymphoma
Parul Ichhpujani, MD
Behin Barahimi, MD
Carol L. Shields, MD
Ralph C. Eagle, Jr., MD
L. Jay Katz, MD
ABSTRACT
This case report presents canaloplasty as a bleb-free sur-
gical option for lowering intraocular pressure in cases
with postoperative conjunctival scarring. [Ophthalmic
Surg Lasers Imaging 2011;42:e10-e11.]
INTRODUCTION
Non-penetrating surgery has recently emerged as a
potential alternative to traditional guarded filtration sur-
gery in the surgical treatment of glaucoma.
1,2
We report
for the first time that canaloplasty can be considered as
a surgical option when a trabeculectomy cannot be per-
formed following excision of a conjunctival tumor.
CASE REPORT
A 72-year-old man with pigmentary glaucoma (pre-
viously diagnosed) underwent a trabeculectomy in his
right eye in 1994. Visual acuity in both eyes was 20/20.
Intraocular pressure (IOP) was 12 and 22 mm Hg in the
right and left eyes, respectively. Gonioscopy showed an
open angle with 2+ pigmentation in both eyes. Topical
therapy included bimatoprost 0.03% at bedtime in both
eyes and timolol 0.5% in morning in the left eye. Slit-
lamp examination the right eye revealed an avascular bleb
(Fig. 1A). The cup–disc ratio was 0.7 in both eyes (average
sized disc). Humphrey visual field testing (central 24-2
threshold test) showed a nasal step in the right eye (mean
deviation = -2.45 dB; pattern standard deviation = 6.78
dB) and an early superior arcuate defect in the left eye
(mean deviation = -3.85 dB; pattern standard deviation =
3.43 dB). Retinal tomography showed a rim area of 0.60
mm
2
in the right eye and 1.95 mm
2
in the left eye.
Biomicroscopy revealed a salmon-colored subepithe-
lial conjunctival mass measuring 25 3 15 3 3 mm in the
superomedial fornix of the left eye (Fig. 1A).The mass was
completely excised and treated with adjuvant cryothera-
py.
3
Histopathology disclosed an extranodular marginal
zone lymphoma of mucosa-associated lymphoid tissue.
Following excision, the IOP in the left eye re-
mained elevated at 24 to 26 mm Hg. Surgical op-
tions included an inferior tube shunt or canaloplasty.
Extensive postoperative superior conjunctival scarring
precluded trabeculectomy (Fig. 1B). Non-penetrat-
ing Schlemm’s canaloplasty using the iScience cannula
(iScience Interventional Inc., Menlo Park, CA) was
performed (Fig.1B).
4
Conjunctival peritomy was followed by creation of
a 4.5 3 4.5 mm superficial partial-thickness scleral flap.
A deep scleral flap, 0.5 mm smaller than the superficial
one, was created to gain access to Schlemm’s canal by
careful anterior dissection. Schlemm’s canal was un-
roofed and then both ostia of the canal were dilated with
a microcannula and the iTrack microcatheter (iScience
Interventional Inc.) was advanced in small steps into the
complete circumference of the canal, injecting minuscule
amounts of high viscosity viscoelastic every 1 or 2 clock-
hours to dilate the canal to a width of approximately 300
From the Glaucoma Service (PI, BB, LJK), the Oncology Service (CLS), and the Department of Pathology (RCE), Wills Eye Institute, Philadelphia, Pennsylvania.
Originally submitted January 14, 2010. Accepted for publication December 2, 2010. Posted online February 10, 2011.
The authors have no financial or proprietary interest in the materials presented herein.
Address correspondence to L. Jay Katz, MD, Glaucoma Service, Wills Eye Institute, 840 Walnut Street, Philadelphia, PA 19107. E-mail: ljk22222@aol.com
doi: 10.3928/15428877-20110203-01
■ CASE REPORT ■