*Corresponding Author Address: Dr. Prashant L. Rasale, Asst. Professor, Dept of Shalyatantra, A & U Tibbia College, karol bagh New Delhi, India World Journal of Pharmaceutical Sciences ISSN (Print): 2321-3310; ISSN (Online): 2321-3086 Published by Atom and Cell Publishers © All Rights Reserved Available online at: http://www.wjpsonline.org/ Original Article Assessment of analgesic property of Ciccus Qudrangularis in the patients of bone fracture by using visual analogue scale Dr. Subhash Y. Raut 1 , Dr. Prashant L. Rasale 2 1 Professor & HOD, Dept. of Shalyatantra Govt. Ayurved College Nagpur 2 Asst. Professor, Dept. of Shalyatantra A & U Tibbia College, Karol Bagh, New Delhi, India Received: 10-02-2017 / Revised: 28-04-2017 / Accepted: 15-05-2017 / Published: 27-05-2017 ABSTRACT Cissus quadrangularis has been used by ancient period for promotion of fracture healing and well known as “Hadjod”. A vast drug review shows that this drug also possess analgesic activity. Various animal studies reports are available over this analgesic and anti-inflammatory activity of drug Cissus quadrangularis. The analgesic effect of this plant when used in bone fractures may be of great value in relief of pain which is a constant feature in these cases. As it compared well with acetyl salicylic acid in its analgesic response, the nature of its chemically active constituents needs to be explored .The pain VAS is a unidimensional measure of pain intensity which has been widely used in diverse adult populations. Our main purpose was to evaluate the analgesic property of this drug in patients of bone fracture having pain and secondary objective was to prepare a scientific, valid document over analgesic property of present drug in terms of visual analogue score. It is seen that drug Cissus quadrangularis has significant impact over pain in terms of VAS so it can be used as analgesic agent in various painful conditions. Keywords: fracture, bhagna, asthishrunkhala, visual analogue scale, hadjod INTRODUCTION Cissus quadrangularis (Linn) has been used by common man in India for promotion of fracture healing and well known as “Hadjod”. It is a common perennial climber, which is distributed throughout India particularly in tropical regions. It requires warm tropical climate and propagated by stem cuttings in months of June and July. It is a climbing herb, tendrils simple, opposite to the leaves, leafless when old. Leaves simple or lobed, cordate, broadly ovate or reniform, serrate, dentate, sometimes 3-foliate and glabrous. Flowers small, greenish white, bisexual, tetramerous, in umbellate cymes, opposite to the leaves. Calyx is cup shaped. Fruit globose or obovoid fleshy berries, succulent, very acrid, dark purple to black, one seeded; seeds ellipsoid or pyriform. Stem is buff colored with greenish ting, dichotomously branched, sub- angular, glabrous, fibrous and smooth. Photochemical screening of Cissus quadrangularis revealed high contents of ascorbic acid, carotene, anabolic steroidal substances, and calcium. The stem contains two asymmetric tetracyclic triterpenoids, and two steroidal principles. The presence of β-sitosterol, δ-amyrin, δ-amyrone, and flavanoids (quercetin) having different potential metabolic and physiological effects has also been reported. 1. Drug (Asthishrunkhala) review Latin name : Cissus quadrangularis CLASSIFICATION: Kingdom : Plantae Division : Magnoliophyta Class : Magnoliopsida Order : Vitales Family : Vitaceae Genus : Cissus