© American Association of Pharmaceutical Scientists 2017
S. El-Khamisy (ed.), Personalised Medicine, Advances in Experimental Medicine and Biology
1007, DOI 10.1007/978-3-319-60733-7_4
The Emerging Role of Proteomics
in Precision Medicine: Application
in Neurodegenerative Diseases
and Neurotrauma
Rana Alaaeddine, Mira Fayad, Eliana Nehme,
Hisham F. Bahmad, and Firas Kobeissy
Abstract
Inter-individual variability in response to pharmacotherapy has provoked
a higher demand to personalize medical decisions. As the field of pharma-
cogenomics has served to translate personalized medicine from concept to
practice, the contribution of the “omics” disciplines to the era of precision
medicine seems to be vital in improving therapeutic outcomes. Although
we have observed significant advances in the field of genomics towards
personalized medicine, the field of proteomics-with all its capabilities- is
still in its infancy towards the area of personalized precision medicine.
Neurodegenerative diseases and neurotrauma are among the areas where
the implementation of neuroproteomics approaches have enabled neuro-
scientists to broaden their understanding of neural disease mechanisms
and characteristics. It has been shown that the influence of epigenetics,
genetics and environmental factors were among the recognized factors
contributing to the diverse presentation of a single disease as well as its
treatment establishing the factor–disease interaction. Thus, management
of these variable single disease presentation/outcome necessitated the
need for factoring the influence of epigenetics, genetics, epigenetics, and
other factors on disease progression to create a custom treatment plan
unique to each individual. In fact, neuroproteomics with its high ability to
decipher protein alterations along with their post translational modifica-
tions (PTMs) can be an ideal tool for personalized medicine goals includ-
R. Alaaeddine
Department of Pharmacology and Therapeutics,
Faculty of Medicine, American University of Beirut,
Beirut, Lebanon
M. Fayad
Biomedical Engineering Program, Faculty of
Engineering and Architecture and Faculty of
Medicine, American University of Beirut,
Beirut, Lebanon
4
E. Nehme • F. Kobeissy (*)
Department of Biochemistry and Molecular Genetics,
Faculty of Medicine, American University of Beirut,
Beirut, Lebanon
e-mail: firasko@gmail.com
H.F. Bahmad (*)
Department of Anatomy, Cell Biology and
Physiological Sciences, Faculty of Medicine,
American University of Beirut, Beirut, Lebanon
e-mail: hfbahmad@gmail.com
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28