This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process, which may lead to differences between this version and the Version of Record. Please cite this article as doi: 10.1111/jebm.12227. This article is protected by copyright. All rights reserved. ARTICLE Laser fluorescence of caries detection in permanent teeth in vitro: a systematic review and meta- analysis Maria Inês Rosa, Vilson Sampaio Schambeck, Eduardo Ronconi Dondossola, Maria Cecília Manenti Alexandre, Lisiane Tuon, Antonio Jose Grande, Fernando Hugo Universidade do Extremo Sul Catarinense Ringgold standard institution Criciuma, SC, Brazil Running title: Laser fluorescence and caries detection Correspondence: Maria Inês da Rosa, Universidade do Extremo Sul Catarinense Ringgold standard institution Criciuma, Rua Cruz e Souza, 510, Bairro Pio Correa-CEP, 88811-550 Criciúma, SC, Brazil; Tel.:+55 48 34339976; fax: þ55 48 34335766; Email: mir@unesc.net Key words: laser fluorescence, caries, systematic review, meta-analysis Received on May 30 th , 2016; Accept on June 23 th , 2016