International Journal of Sciences: Basic and Applied Research (IJSBAR) ISSN 2307-4531 (Print & Online) http://gssrr.org/index.php?journal=JournalOfBasicAndApplied --------------------------------------------------------------------------------------------------------------------------- 189 The Potential Gonad of Diadema Setosum as a Healthy Food to Improve the Nutritional Status of Coastal’s Children Wa Ode Salma a , Indria Hafizah b , Tomy Nurtamin c , La Ode Muhammad Yasir Haya d* , Suryani As´ad e a Department of Nutrition, Faculty of Medicine, Halu Oleo University, Kendari, Indonesia b Department of Microbiology, Faculty of Medicine, Halu Oleo University, Kendari, Indonesia c Department of Physiology, Faculty of Medicine, Halu Oleo University, Kendari, Indonesia d Department of Marine science, Faculty Fisheries and Marine Science Halu Oleo University, Kendari, Indonesia e Depsrtement of Nutrition, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia d Email : laode.haya@uho.ac.id Abstract The problem of malnutrition in the household, especially for children who settled the coastal region are frequent. It required to use the potential of indigenous foods such as gonad of Diadema setosum, which has been known to contain macro and micro nutrient substances are highly qualified and the results of microbiological tests by culture, was not contaminated by Salmonella sp and E. coli so it was safe for consumption. The purpose of our study, assessing the effect of gonad of Diadema setosum extracts to weight gain in animal models of strain BALB/c mice were induced by lipopolysaccharide (LPS). The method of weight assessment was using a special tool scales OHAUS Triple Beam Balance. Induction of LPS 0.2 ml x 10 3 ml / CFU intraperitoneally. The results showed that the intervention group body weight dose of 200 mg / kg group increased higher than the dose of 100 mg / kg opposite occurred the control group weight loss was significantly (p value = 0.001). ------------------------------------------------------------------------ *Corresponding author.