1 Receptor protein tyrosine phosphatase RPTPα controls epithelial adherens junctions, linking E-cadherin engagement to c-Src signaling to cortactin Marta Truffi 1 , Véronique Dubreuil 1* , Xuan Liang 3 , Nathalie Vacaresse 2,# , Fabienne Nigon 1 , Siew Ping Han 3,% , Alpha S. Yap 3 , Guillermo A. Gomez 3 and Jan Sap 1,2,* 1 Université Paris Diderot, Sorbonne Paris Cité, Epigenetics and Cell Fate, UMR 7216 CNRS Bâtiment Lamarck, Case 7042, 35 rue Hélène Brion, F-75205 Paris Cedex 13, France 2 Biotech Research and Innovation Centre and Department of Biomedical Sciences, Faculty of Health Sciences, University of Copenhagen, Ole Maaløes Vej 5, 2200 Copenhagen N, Denmark 3 Division of Molecular Cell Biology, Institute for Molecular Bioscience, University of Queensland, St. Lucia, Brisbane, Australia 4072 # Present address: Department of Immunology, The University of Toronto, Sunnybrook Research Institute, 2075 Bayview Avenue, Toronto, ON M4N 3M5, Canada % Present address: Centre for BioImaging Sciences, National University of Singapore, 14 Science Drive 4, S1A Level 2, Singapore 117557 * Joint corresponding authors Tel +33 1 5727 8916 Fax +33 1 5727 8911 e-mail jansap@fastmail.fm or veronique.dubrueil@univ-paris-diderot.fr © 2014. Published by The Company of Biologists Ltd. Journal of Cell Science Accepted manuscript JCS Advance Online Article. Posted on 20 March 2014