Wa N-f’whop zyxwvutsrqponmlkjihgfedcbaZYXWVUTS f,amad. &FM. Ps~&at. 1997. Vol. 21. pp. 273-296 Copyr@ht 0 1997Elseviw sdenn Inc. PlintedintheusA. Aurlght8rrsed 0278~5846/97 %32.00 + .OO zyxw ELSEVIER PII 9027~58443(97)~2-X A PHARMACOLOGICAL ANALYSIS OF SEROTONERGIC RECEPTORS: EFFECTS OF THEIR ACTIVATION zyxwvutsrqponmlkjihgfedcbaZYXWVUTSRQP OF BLOCKADE IN LEARNING ALFRED0 MENESES and ENRIQUE HONG Seccibn de Terapeutica Experimental Departamento de Farmacologla y Toxicologla, CINVESTAV-IPN Tepepan, Mexico D.F., Mexico. (Final form, November 1996) zyxwvutsrqponmlkjihgfedcbaZY 1. 2. 3. 4. 5. 6. zyxwvutsrqponmlkjihgfedcbaZYXWVUTSRQPONMLKJIHGFEDCBA a. 9. 10. Contents Abstract Introduction Behavioral and Pharmacological Validity of the Autoshaping as Learning Model Effects of the 5-HT Depletion on Learning Effects of Fluoxetine (a 5-HT Uptake Inhibitor) EtYects of 5-HT,, Receptors Agonists and Antagonists Effects of 5-HT,, and 5-HTWBRC Receptors Agonists and Antagonists Effects of 5-HT, Receptors Agonists and Antagonists Effects of 5-HT. Receptors Agonists and Antagonists 5-HT Receptor Agonists and Antagonists on the Consolidation of Learning Conclusions Acknowledgments References Abstract Meneses, Alfredo and Enrique Hong. A Pharmacological analysis of serotonergic receptors: Effects of their activation or blockade in learning. Prog. Neuro-Psychopharmacol.& Biol. Psychiat. 1997, a., pp. 273-296. Cawrlght 0 1997 Elsevter science Inc. 1. The authors have tested several 5HT selective agonists and antagonists (5-HTIAI,s, 5-HT,,,, 5HT, or !%HT,), an uptake inhibitor and 5-HT depletors in the autoshaping learning task. 2. 3. The present work deals with the receptors whose stimulation increases or decreases learning Impaired consolidation of learning was observed after the presynaptic activation of 5-HT,,, 5-HT, or 5-HT, or the blockade of postsynaptic 5-HT,,,, receptors. 273