ISSN: 2320-5407 Int. J. Adv. Res. 5(7), 2092-2100 2092 Journal Homepage: - www.journalijar.com Article DOI: 10.21474/IJAR01/4946 DOI URL: http://dx.doi.org/10.21474/IJAR01/4946 RESEARCH ARTICLE ANTI-ULCER ACTIVITY OF TERMINALIA LAXIFLORA ENGL. AND DIELS LEAVES EXTRACTS AGAINST ASPIRIN INDUCED GASTRIC ULCER IN RATS. Medhat M. Menshawy 1 , Mohamed A. El Raey 2 , Abdel Hamid A. Hamdy 3 and Abdel Razik H. Farrag 4 . 1. Department of Biology, Center of Basic Sciences, Misr University for Science and Technology, 6 th October City. 2. Departments of Phytochemistry & Plant Systematic. 3. Chemistry of Natural & Microbial Products. 4. Pathology, National Research Centre, Dokki, Cairo, Egypt. …………………………………………………………………………………………………….... Manuscript Info Abstract ……………………. ……………………………………………………………… Manuscript History Received: 24 May 2017 Final Accepted: 26 June 2017 Published: July 2017 Key words:- Antiulcer ulcer, Terminalia, aspirin, rats, plant phenolics. Background/Aim: Gastric ulcer is one of the most widespread gastrointestinal disorders resulting from weakness of a gastric mucosal defense. Several drugs are available to address ulcer; however, these drugs are associated with several side effects. Previous studies have confirmed the efficacy of herbal plants extracts for possible treatment of this disease. This research aims to evaluate the antiulcer properties of Terminalia laxiflora extracts. Methods: Water and its fractions, total methanol, dichloromethane, ethyl acetate, butanol extracts from the leaves of Terminalia laxiflora were evaluated for their antiulcer activity using aspirin as ulcerogen in rats. All administration was given one hour prior to aspirin. Macroscopic, hisopathological and histochemical examinations were performed the effect of these extracts on ulcer. Results: All extracts showed significant inhibitory activity. The percentages of inhibition for the different extracts equal to 54.21, 64.86, 61.71, 76.84, 75.92, 79.47, and 86.05 % for water 1, water 2, methanol, DCM, ethyl acetate, and butanol as compared to non-pretreated aspirin group. Butanol extract was found to possess remarkable ulcer-protective properties at 50 mg/kg when compare to other the other extracts. The effect of ulcer protection 86.05 % was produced and standard drug, Ranitidine, gave 81.57% of ulcer protection, respectively. Conclusion: We conclude that Terminalia laxiflora extracts are potential sources of new antiulcer agents. Copy Right, IJAR, 2017,. All rights reserved. …………………………………………………………………………………………………….... Introduction:- Peptic ulcer disease is disorder used to describe a heterogeneous group of condition with ulcerations. It is characterized by the disruption of the normal mucosal integrity of the esophagus, stomach, or duodenum (Kumar, et al, 2011). Gastric ulcer is one of the most common disorders (Alkofahi, and Atta 1999). The continuously exposed to agents such as pepsin, acid, bacterial products, bile acids, and steroidal and non-steroidal anti-inflammatory drugs (NSAIDS) increases the gastric ulcer prevalence (Mota, et al, 2009). These agents have been implicated in the pathogenesis of gastric ulcer, including enhanced gastric acid and pepsin secretion, inhibition of prostaglandin synthesis and cell proliferation growth, diminished gastric blood flow and gastric motility (Toma, et al, 2005). Corresponding Author:- Medhat M. Menshawy. Address:- Department of Biology, Center of Basic Sciences, Misr University for Science and Technology, 6 th October City.