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© Europa Digital & Publishing 2014. All rights reserved.
CLINICAL RESEARCH
EuroIntervention 2014; 10-online publish-ahead-of-print April 2014
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*Corresponding author: Interventional Cardiology Dept, Hôpital Cardiologique – Hospices Civils de Lyon, 28 avenue Lépine,
69677 Bron Cedex, France. E-mail: gilles.rioufol@univ-lyon1.fr
Influence of arterial hypotension on fractional flow reserve
measurements
Florence Verdier-Watts
1
, MD; Gilles Rioufol
1,2
*, MD, PhD; Nathan Mewton
2
, MD, PhD; Ingrid Sanchez
1
, MD;
Lisa Green
1
, MD; Eric Bonnefoy-Cudraz
1
, MD, PhD; Gérard Finet
1,2
, MD, PhD
1. Interventional Cardiology Department, Hospices Civils de Lyon, Bron, France; 2. INSERM U1060, CarMeN, SFR Lyon-Est
(CNRS UMS3453 - INSERM US7), Lyon, France
Abstract
Aims: To assess fractional flow reserve (FFR) variability in case of arterial hypotension in the clinical set-
ting. FFR measurement is supposed to be independent of haemodynamics; there is, however, a strong rela-
tionship between trans-stenotic pressure variation and coronary flow. Non-clinical models suggest an inverse
relationship between arterial pressure and FFR, but no clinical data have as yet confirmed this hypothesis.
Methods and results: ,Q FDVH RI DUWHULDO K\SRWHQVLRQ PHDQ DUWHULDO SUHVVXUH >3D@ PP+J GXULQJ URX-
tine clinical FFR measurement (FFR
1
), a second measurement (FFR
2
) was performed after pressure normali-
VDWLRQ E\ PJ ,9 SKHQ\OHSKULQH )RXUWHHQ LQWHUPHGLDWH FKURQLF VWHQRVHV '6 ))5
1
LQ PDOH SDWLHQWV VKRZHG PP+J 3D DW WKH WLPH RI PHDVXUHPHQW $IWHU SKHQ\OHSKULQH 3D LQFUHDVHG
WR PP+J DQG ))5
2
GHFUHDVHG WR S ZLWKRXW KHDUW UDWH YDULDWLRQ $IWHU 3D HOHYDWLRQ
RI FDVHV ZLWK ))5
1
! FKDQJHG WR ))5
2
Conclusions: In the present study, in case of arterial hypotension, FFR decreased with rising pressure.
Whether repeated FFR measurement after haemodynamic normalisation is of clinical benefit remains at this
point speculative and should be validated in a larger data set.
KEYWORDS
• arterial hypotension
• fractional flow
reserve