International Journal of Clinical Medicine Research 2017; 4(3): 21-25 http://www.aascit.org/journal/ijcmr ISSN: 2375-3838 Keywords Interleukins, Profile, Subjects, Schistosomes, Enwan Received: March 31, 2017 Accepted: May 31, 2017 Published: August 3, 2017 Interleukin (IL) - 1α, IL – 7 and IL – 13 Profile Among Enwan Community, Edo State, Nigeria with Schistosoma haematobium Infection Imarenezor Edobor Peter Kenneth 1 , Iyamu Mercy Itohan 2 , Nmorsi Onyebiguwa Patrick Godwin 3 1 Tropical Diseases Unit, Department of Microbiology, Faculty of Pure and Applied Sciences, Federal University, Wukari, Nigeria 2 Department of Microbiology, Faculty of Life Sciences, Ambrose Alli University, Ekpoma, Nigeria 3 Department of Medical Microbiology and Parasitology, Delta State University, Abraka, Nigeria Email address kimarenezor@yahoo.com (I. E. P. Kenneth) * Corresponding author Citation Imarenezor Edobor Peter Kenneth, Iyamu Mercy Itohan, Nmorsi Onyebiguwa Patrick Godwin. Interleukin (IL) - 1α, IL – 7 and IL – 13 Profile Among Enwan Community, Edo State, Nigeria with Schistosoma haematobium Infection. International Journal of Clinical Medicine Research. Vol. 4, No. 3, 2017, pp. 21-25. Abstract Schistosomiasis is an endemic parasitic disease exclusively located in tropical Africa, Asia and North America. The infection processes and indeed the control of this infection partly require an understanding of cytokine immune responses to the disease. This study therefore aims at determining the profiles of cytokines (interleukins) (IL) (IL - 1α, IL - 7 and IL – 13) among schistosomes positive individuals. The investigation was carried out in Ewan in Edo State, Nigeria. Sera from 35 seropositive subjects were categorized as lightly and heavily positive. Also, 16 of these 35 seropositive subjects demonstrated parasites in the blood and as a result were further grouped into lightly infected (n=4) and heavily infected (n=12) of schistosomiasis based on the demonstration of Schistosoma haematobium infection. Sera of seropositive subjects were subjected to IL - 1α, IL - 7 and IL – 13 assays. In the serum, IL-1α levels were significantly higher among the heavily positive subjects than the control subjects (p<0.05). Conversely, depressed level of IL-1α was seen for schistosomiasis lightly positive subjects (p<0.001). IL-7 level was significantly lower in heavily positive individuals than control subjects and lightly positive IL-7 level was significantly depressed (p<0.05). There was no significant difference in IL-13 levels among schistosomes infected individuals and their non- infected counterparts. The depressed levels of serum IL-1α and IL -7 should serve as markers for individuals with lightly positive schistosomiasis infection in Ewan, Edo State, Nigeria. 1. Introduction Urinary schistosomiasis caused by Schistosoma haematobium is one of the most common tropical diseases which poses serious health hazard due to its associated morbidities. Globally, over 153 million are infected with this parasitic infection [1]. In Nigeria, pockets of foci of infections have been documented in various parts of the country [2]. In developing nations, the true epidemiological picture appears difficult because of inadequate research in this direction despite its relevance in planning its