ͳ Human breast tumor cells induce self-tolerance ͳ mechanisms to avoid NKG2D-mediated and DNAM- ʹ mediated NK-cells recognition ͵ Ͷ Running title: Breast cancer cells interactions with NK-cells anti-tumor immunity ͷ ͸ Emilie Mamessier 1,2 , Aude Sylvain 1* , François Bertucci 1,3* , Rémy Castellano 1,4 , ͹ Pascal Finetti 3 , Gilles Houvenaeghel 3 , Emmanuelle Charaffe-Jaufret 1,3 , Daniel ͺ Birnbaum 1,3 , Alessandro Moretta 5 and Daniel Olive 1,3 ͻ ͳͲ 1 Centre de Recherche en Cancérologie de Marseille, INSERM UMR U891, 27 Bd Lei ͳͳ Roure, 13009 Marseille, France ͳʹ 2 Current affiliation: Laboratory Genomic Instability and Human Hemopathies Centre ͳ͵ d’Immunologie Marseille-Luminy (CIML), Parc Scientifique de Luminy, 13288 ͳͶ Marseille, France. ͳͷ 3 Institut Paoli-Calmettes, 232 Bd Ste Marguerite, 13009 Marseille, France ͳ͸ 4 TrGET, Centre de Recherche en Cancérologie de Marseille, INSERM UMR U891, ͳ͹ 27 Bd Lei Roure, 13009 Marseille, France ͳͺ 5 D.I.ME.S., University di Genova, Genova, Italy ͳͻ * These two authors equally contributed to this work. ʹͲ Research. on August 28, 2017. © 2011 American Association for Cancer cancerres.aacrjournals.org Downloaded from Author manuscripts have been peer reviewed and accepted for publication but have not yet been edited. Author Manuscript Published OnlineFirst on September 21, 2011; DOI: 10.1158/0008-5472.CAN-11-0792