World Journal of Pharmaceutical Sciences ISSN (Print): 2321-3310; ISSN (Online): 2321-3086 Available online at: http://www.wjpsonline.org/ Original Article Address for Correspondence: Dr. Abbas Dawwas Metter Al-Maliki, Chemistry Department, College of Education for Pure Sciences, University of Basrah, Iraq How to Cite this Article: Abbas Dawwas Metter Al-Maliki and Raneen Salim Swadi Al-Hilfi. Evaluation of Hypoglycemic Effect of Two flavonoidic Compounds Isolated from Iraqi Phoenix dactylifera (Gintar) Leaflets in Alloxan-Induced Diabetic Rabbits. World J Pharm Sci 2017; 5(7): 61-71. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial- ShareAlike 4.0 International License, which allows adapt, share and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. © 2017 World J Pharm Sci Evaluation of Hypoglycemic Effect of Two flavonoidic Compounds Isolated from Iraqi Phoenix dactylifera (Gintar) Leaflets in Alloxan-Induced Diabetic Rabbits Abbas Dawwas Metter Al-Maliki and Raneen Salim Swadi Al-Hilfi Chemistry Department, College of Education for Pure Sciences, University of Basrah, Iraq Received: 22-05-2017 / Revised Accepted: 15-06-2017 / Published: 25-06-2017 ABSTRACT Diabetes Mellitus (DM) is a chronic metabolic disorder disease resulting from lack in action of insulin hormone. Thin Layer Chromatography (TLC) results showed presence of two flavonoidic spots from phoenix dactylifera(Gintar) leaflets have rate of flow equal to 0.35 , 0.4 . So These compounds were separated by column chromatography (CC) then they were identified by infra-red spectrum and gas chromatography-mass spectrum technique and they were phenol,2,2 ' -methylene bis[6-(1,1-dimethyl)- 4-methyl and phenol,2,2 ' -methylene bis [6-methoxy-3-(2-propenyl). Hypoglycemic effects of these active compounds were investigated and estimated in normalglycemic and hyperglycemic rabbits. The blood glucose levels in fasted normal rabbits were 137.66, 117.5, 106.88, 100.50 and 80.66 mg/100ml at 0,2,4,6 and 24 hr respectively from oral administration time. Also the blood glucose levels in fasted diabetic rabbits were 375.83, 315.50, 213.66, 152.35 and 145.50 mg/100ml at 0,2,4,6 and 24 hr respectively. The two flavonoids had no toxic effect on hemolysis of red blood cells so these active compounds can be used safely to treat diabetes mellitus disease. Keywords: Hypoglycemic Effect, flavonoidic compounds, Diabetic rabbits, Phoenix dactylifera (Gintar), Mass spectrum