1 Genetic analyses of PBP determinants in multidrug-resistant Streptococcus pneumoniae 1 serogroup 19 CC320/271 clone with high level resistance to third generation cephalosporins. 2 Margaret Ip 1 * 3 Irene Ang, 1 4 Veranja Liyanapathirana, 1 5 Helen Ma, 1 6 Raymond Lai, 1 7 1 Department of Microbiology, Faculty of Medicine, the Chinese University of Hong Kong, 8 Prince of Wales Hospital, HKSAR. 9 10 11 *Corresponding author: margaretip@cuhk.edu.hk 12 Mailing address: Department of Microbiology, Chinese University of Hong Kong, The Prince of 13 Wales Hospital, Hong Kong. Phone: (852) 2632 1265 Fax: (852) 2647 3227 14 15 Running title: Multidrug-resistant S. pneumoniae 19 CC320/271 16 17 Keywords: Streptococcus pneumoniae, serotype 19F, beta-lactam resistance, penicillin binding 18 protein 19 20 21 22 23 AAC Accepted Manuscript Posted Online 27 April 2015 Antimicrob. Agents Chemother. doi:10.1128/AAC.00094-15 Copyright © 2015, American Society for Microbiology. All Rights Reserved. on September 3, 2017 by guest http://aac.asm.org/ Downloaded from