Pediatric Urology
Quality Assessment of Hypospadias Repair
with Emphasis on Techniques Used and
Experience of Pediatric Urologic Surgeons
Rafal Chrzan, Pieter Dik, Aart J. Klijn, and Tom P. V. M. de Jong
OBJECTIVES To assess outcomes in hypospadias repair at our institution, as compared with the literature, with
repair technique and surgeon considered as risk factors.
METHODS The results of 299 primary hypospadias corrections were analyzed. All procedures were performed
by three experienced pediatric urologists. Mean patient age at operation was 16.3 months.
Follow-up was between 6 months and 5.5 years. Distal hypospadias repair was carried out in 242
patients, with tubularized incised plate reconstruction in 100 patients, advancement in 128, and
the Mathieu technique in 14.
RESULTS During follow-up, complications occurred overall in 93 patients (31%). For distal hypospadias
complications occurred in 59 patients (24%). The most common findings for distal hypospadias
were urethral fistulas (14.4%). The complication rate depended on the severity of the anomaly
(0 glanular, 28% pericoronal, and 63% proximal) and the chosen technique (16% advancement
technique versus 60% tubular techniques). We found statistically significant differences in
complication rates between operating surgeons.
CONCLUSIONS Complications after hypospadias surgery are frequent. They are multifactorial and depend mainly
on the type of the anomaly, the chosen technique, and the experience of the surgeon. More
studies are needed to obtain an internationally accepted quality indicator for the outcome of
hypospadias repair. UROLOGY 70: 148 –152, 2007. © 2007 Elsevier Inc.
O
ver the years, more than 300 operations have
been proposed for hypospadias repair. A contin-
uous search exists for the optimal solution be-
cause of the high complication rates, as high as 50% in
long-term follow-up. Retrospectively, it is apparent that
most new solutions are modifications of older tech-
niques.
1–4
Besides a satisfactory functional result, much attention
currently is given to cosmesis and a minimization of
psychological trauma. Obviously, complications have a
negative influence on the final results.
4,5
Success depends on the severity of the malformation.
More distal hypospadias yield better results, but compli-
cation rates in long-term follow-up can still be high.
4,6
Complications are widely discussed in the literature but
with little specific advice on how to avoid them. Quality
of care is becoming increasingly important; as a result,
governmental health care authorities, insurance compa-
nies, and the public all want to have quality indicators for
both doctors and hospitals. There is widespread interna-
tional agreement regarding indicators for structure (who
operates?) and process (how is it done?) for hypospadias
repair. However, there is no agreement as to a quality
indicator concerning outcome.
We conducted a quality assessment for the outcome of
hypospadias repair at our institution. In addition, we
assessed the outcome of distal repairs, with operating
pediatric urologic surgeon considered as one risk factor
influencing the final results.
MATERIAL AND METHODS
We retrospectively analyzed the results of 299 primary hypos-
padias corrections performed between June 1999 and June 2004.
Only those patients who underwent one-step reconstruction
within the first 48 months of life with a minimum of 6 months’
follow-up were included. Mean follow-up was 29 months
(range, 6 months to 5.5 years). The mean age at operation was
16.3 months (range, 8 to 48 months). The tubularized incised-
plate (TIP) technique was performed in 133 patients, followed
by advancement techniques (techniques that do not require a
suture line into the urethra) in 128. This left a miscellaneous
group of 38 patients (onlay, Duckett, and Mathieu techniques).
Antibiotics (amoxicillin-clavulanic acid) were given periop-
eratively to all patients. Prolonged prophylaxis with tri-
methoprim 2 mg/kg once daily and antimuscarinics (oxybuty-
nin 0.4 mg/kg/day in 3 gifts) were routinely used in all children
who had been catheterized for more than 12 hours. All surgery
From the Department of Pediatric Urology, University Children’s Hospital, University
Medical Center Utrecht, Utrecht, The Netherlands
Reprint requests: Rafal Chrzan, M.D., Ph.D., Department of Pediatric Urology,
University Children’s Hospital, Univeristy Medical Center Utrecht, Lundlaan 6,
3584EA Utrecht, The Netherlands. E-mail: rchrzan@umcutrecht.nl
Submitted: September 1, 2006; accepted (with revisions): January 30, 2007
148 © 2007 Elsevier Inc. 0090-4295/07/$32.00
All Rights Reserved doi:10.1016/j.urology.2007.01.103