Journal of Computational Intelligence in Bioinformatics. ISSN: 0973-385X Volume 1 Number 2-3 (2008) pp. 93–108 © Research India Publications http://www.ripublication.com/jcib.htm DLact: An Antimicrobial Resistance Gene Database Reema Singh Scientist-I Biomedical Informatics Center Indian Council of Medical Research Ansari Nagar, New Delhi - 110029, India E-mail:reemas@icmr.org.in Suchir Scientist-I Biomedical Informatics Center Indian Council of Medical Research Ansari Nagar, New Delhi - 110029, India E-mail:suchir@icmr.org.in Harpreet Singh* Scientist B Biomedical Informatics Center Indian Council of Medical Research Ansari Nagar, New Delhi - 110029, India E-mail:hsingh@icmr.org.in Abstract Lactamases are the main cause of antimicrobial resistance in the bacterial pathogens. Here, we introduce DLact, a curated collection of lactamase like proteins from bacterial genomes. The database currently contains 2020 lactamase like genes from 814 sequenced bacterial genomes. Of which 1971 (97.57%) were present on chromosome and only 49 (2.42%) were present on plasmids. The database can be searched using text and sequence queries. Diversity at the taxonomic, microbial ecology, domain length and sequence was studied. DLact database may be used for variety of biomedical research such as to develop diagnostic primers and probes and in identifying pathways controlling/affecting the expression of antimicrobial genes, comparative protein modeling and drug designing, as well as those interested in broad subjects such as lateral gene transfer and Codon usage. The database will be updated bi-yearly using in-house