Original Research Article DOI: 10.18231/2394-2126.2017.0077 Indian Journal of Clinical Anatomy and Physiology, July-September, 2017;4(3):304-307 304 A correlation between thyroid hormone profile and physical parameters in normal person Jitendra Patel 1,* , Jasmin Parmar 2 , Anita Verma 3 , Pratik Akhani 4 1,4 Assistant Professor, GAIMS, Bhuj, Gujarat, 2 Assistant Professor, M. P Shah Govt Medical College, Jamnagar, Gujarat, 3 Professor & HOD, Dept. of Physiology, NHL MMC, Ahmedabad, Gujarat *Corresponding Author: Email: dr.jrpatel84@gmail.com Abstract Introduction: The aim of the study was to correlate the thyroid hormone profile with the age, height, weight, body mass index (BMI), with body fat percentage (BF%) in apparently healthy person. Materials and Method: 84 normal subjects were included in the present study. In thyroid hormone profile S. TSH, Total S. T3, and Total S. T4 were estimated by lumax chemiluminescence immunoassay strip reader in the laboratory. Height, weight and BMI were recorded by standard method and BF% was calculated by the formula. Analysis was done by SPSS software. Result: Of 84 subjects, 39 were males and 45 were females. The correlation coefficient of thyroid hormone profile: For S. TSH (r=+0.261, p=0.02), (r=+0.064, p=0.57), (r=+0.330, p=0.00), (r=+0.368, p=0.00), (r=+0.387, p=0.00); For S. T3 (r=-0.299, p=0.01), (r=-0.208, p=0.06), (r=-0.447, p=0.00), (r=-0.377, p=0.00), (r=-0.257, p=0.02); For S. T4 (r=-0.086, p=0.44), (r=-0.174, p=0.11), (r=-0.365, p=0.00), (r=-0.297, p=0.00), (r=-0.072, p=0.52) with age, height, weight, BMI and BF% respectively. Conclusion: The S. TSH shows significant positive correlation with age, weight, BMI and BF percentage. While S. T3 shows significant negative correlation with age, weight, and BMI and BF percentage and S. T4 shows significant negative correlation with weight and BMI. That suggests the physical parameters also play an important role to determine the thyroid function, as thyroid hormone play an important role in the metabolism of almost all the cell of the body. Keywords: Thyroid hormone, Physical parameters, Normal subjects Received: 20 th April, 2017 Accepted: 26 th May, 2017 Introduction The present study is cross-sectional in design and aimed at understanding the association between thyroid function and physical parameters in apparently healthy euthyroid individuals. Various factors play an important role in the regulation of hormone, physical factors are one of them. Looking at the impact of physical factors on the thyroid hormone level within physiological range is a relatively new approach. To identify the complex interrelationship between thyroid function and physical parameters may help in prevention and treatment of and thyroid dysfunction. Many factors have been found to affect a person’s weight, including lifestyle choices like nutritional behaviour and physical activity, as well as genetics, environmental and endocrinal factors. (1) Thyroid hormone regulates energy metabolism and thermogenesis and plays a critical role in glucose metabolism and lipid metabolism, food intake, and the oxidation of fatty acids. (2) Most studies that have been done on euthyroid individuals have shown that there is a significant association between body mass index (BMI) and thyroid function. (3) From a clinical point of view, obesity and mild thyroid failure are common diseases. More studies are needed to fully understand the extent of the association and translate the findings into practical use in the clinical setting. Aims & Objectives  To correlate the thyroid hormone profile with the age.  To correlate the thyroid hormone profile with height and weight.  To correlate the thyroid hormone profile with body mass index (BMI) and with body fat percentage (BF%). Materials and Method The current study is a cross-sectional design to determine the relationship between thyroid profile and physical parameters. For selection of study subjects; a detailed history was taken and general physical examination and systemic clinical examination were done. The detailed of subject was recorded in case paper. Body weight was measured to the nearest 1.0 kg using mechanical weighing machine (Gebruder Soehnle, West Germany) with subjects wearing minimal clothing and without shoes. Height was measured to the nearest 1.0 cm freestanding without shoes using measure tape (Crown, India). BMI was calculated from following formula (kg/m 2 ). BF% was calculated from formula (Deurenberg P, Weststrate JA, Seidell JC, 1991) BF%=(BMI*1.20)+(Age*0.23)-(Sex*10.8)-5.4 (where BMI in kg/m2; Age in Years; Sex is 1 for male and 0 for female). After written informed consent of subjects, 5 ml venous Blood samples were obtained by aseptic