FXR Modulates Renal Lipid Metabolism, Fibrosis and Diabetic Nephropathy Tao Jiang 1 *, Xiaoxin X. Wang 1 *, Pnina Scherzer 2 , Paul Wilson 1 , James Tallman 1 , Hideaki Takahashi 1 , Jinping Li 1 , Mieko Iwahashi 1 , Eileen Sutherland 1 , Lois Arend 3 , and Moshe Levi 1 1 Division of Renal Diseases and Hypertension, Departments of Medicine, Physiology and Biophysics, Denver VA Med Center and University of Colorado Health Sciences Center, Denver, Colorado, 2 Nephrology and Hypertension Services, Hadassah University Hospital, Jerusalem 91120, Israel 3 Department of Pathology and Laboratory Medicine, University of Cincinnati Medical Center, Cincinnati, Ohio * Equal contribution by the first 2 authors Running Title: FXR, lipid metabolism, and diabetic nephropathy Address Correspondence to: Moshe Levi, M.D. Departments of Medicine, Physiology and Biophysics Division of Renal Diseases and Hypertension University of Colorado Health Sciences Center 4200 East 9 th Avenue Denver, Colorado 80262 E-mail: Moshe.Levi@uchsc.edu Received for publication 22 November 2006 and accepted in revised form 20 July 2007. 1 Diabetes Publish Ahead of Print, published online August 7, 2007 Copyright American Diabetes Association, Inc., 2007